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Titolo:
DECREASE IN MYOMETRIAL BETA-ADRENERGIC RECEPTORS WITH PRENATAL COCAINE USE
Autore:
SMITH YR; DOMBROWSKI MP; LEACH KC; HURD WW;
Indirizzi:
MPB D2210,1500 E MED CTR DR ANN ARBOR MI 48109 UNIV MICHIGAN,MED CTR,DEPT OBSTET & GYNECOL ANN ARBOR MI 00000 WAYNE STATE UNIV,DEPT OBSTET & GYNECOL DETROIT MI 00000
Titolo Testata:
Obstetrics and gynecology
fascicolo: 3, volume: 85, anno: 1995,
pagine: 357 - 360
SICI:
0029-7844(1995)85:3<357:DIMBRW>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
EFFICACY; BINDING; ABUSE; LABOR; TERM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
Y.R. Smith et al., "DECREASE IN MYOMETRIAL BETA-ADRENERGIC RECEPTORS WITH PRENATAL COCAINE USE", Obstetrics and gynecology, 85(3), 1995, pp. 357-360

Abstract

Objective: To determine if cocaine use during pregnancy is associatedwith a reduction in the number or affinity of beta-adrenergic receptors in human myometrium. Methods: Myometrium was obtained at cesarean delivery of five women who reported using cocaine during pregnancy and from ten controls. Saturation binding assays were performed on the myometrial membrane fractions using [I-125]-cyanopindolol to determine beta-adrenergic receptor concentration and affinity. The percentages of beta(1)- and beta(2)-adrenergic receptors were determined in three cocaine users and four control patients by performing competition bindingassays using the beta, antagonist ICI 118,551. Results were compared using unpaired Student t tests. Results: Women who reported using cocaine during pregnancy had a significantly lower mean (+/- standard deviation) concentration of myometrial beta-adrenergic receptors than did controls (22 +/- 8 versus 52 +/- 23 fmol/mg protein, respectively). There was no difference in the receptor affinity constants between cocaine users and controls (16 +/- 2 pmol/L for both groups). The percentages of beta(1)- and beta(2)-adrenergic receptors in the myometrium of the cocaine-use group and control group were similar: 86 +/- 1% beta(2)in the cocaine-use group and 83 +/- 7% beta(2) in the control group. Conclusion: Cocaine use during pregnancy may be associated with a down-regulation of beta-adrenergic receptors in human myometrium. This could result in a decreased capacity for uterine relaxation and, consequently, a predisposition to preterm labor.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 20:38:15