Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
OBESITY IN HETEROZYGOUS CARRIERS OF THE GENE FOR THE BARDET-BIEDL SYNDROME
Autore:
CROFT JB; MORRELL D; CHASE CL; SWIFT M;
Indirizzi:
NEW YORK MED COLL,DIV HUMAN MOLEC GENET,4 SKYLINE DR HAWTHORNE NY 10532 NEW YORK MED COLL,DIV HUMAN MOLEC GENET VALHALLA NY 00000 UNIV N CAROLINA,BIOL SCI RES CTR CHAPEL HILL NC 00000
Titolo Testata:
American journal of medical genetics
fascicolo: 1, volume: 55, anno: 1995,
pagine: 12 - 15
SICI:
0148-7299(1995)55:1<12:OIHCOT>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATAXIA-TELANGIECTASIA; RENAL-DISEASE; WEIGHT; FAMILIES; CHILDREN; TWIN; ENVIRONMENT; RELIABILITY; ACCURACY; VALIDITY;
Keywords:
LAURENCE-MOON-BIEDL SYNDROME; OBESITY; GENETICS; HETEROZYGOTES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
J.B. Croft et al., "OBESITY IN HETEROZYGOUS CARRIERS OF THE GENE FOR THE BARDET-BIEDL SYNDROME", American journal of medical genetics, 55(1), 1995, pp. 12-15

Abstract

Obesity and renal failure are common manifestations in the autosomal recessive Bardet-Biedl (BE) syndrome. Because obesity and hypertensionhave been reported frequently in non-homozygous relatives of BE patients, we hypothesized that BE heterozygotes are predisposed to these conditions. Clinical information was collected from 34 parents of BE homozygotes, who are obligate heterozygotes. The proportion of severely overweight fathers (26.7%) was significantly higher than that in comparably aged United States white males (8.9%). We conclude that the BE gene may predispose male heterozygous carriers to obesity. If BE heterozygotes are 1% of the general population, we estimate that approximately 2.9% of all severely overweight white males carry a single BE gene. The BE parents of both sexes were also significantly taller than U.Ss white men and women of comparable age. (C) 1995 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 05:45:02