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Titolo:
INDUCTION OF THE TRANSCRIPTION FACTORS NF-KB, AP-1 AND NF-AT DURING B-CELL STIMULATION THROUGH THE CD40 RECEPTOR
Autore:
FRANCIS DA; KARRAS JG; KE XY; SEN R; ROTHSTEIN TL;
Indirizzi:
BOSTON UNIV,MED CTR,DEPT MED,ROOM E-501,88 E NEWTON ST BOSTON MA 02118 BOSTON UNIV,MED CTR,DEPT MED BOSTON MA 02118 BOSTON UNIV,MED CTR,DEPT PATHOL BOSTON MA 02118 BOSTON UNIV,MED CTR,DEPT MICROBIOL BOSTON MA 02118 BOSTON UNIV,MED CTR,EVANS MEM DEPT CLIN RES BOSTON MA 02118 BRANDEIS UNIV,ROSENSTIEL CTR,DEPT BIOL WALTHAM MA 02254
Titolo Testata:
International immunology
fascicolo: 2, volume: 7, anno: 1995,
pagine: 151 - 161
SICI:
0953-8178(1995)7:2<151:IOTTFN>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE-C; TUMOR-NECROSIS-FACTOR; ACTIVATED T-CELLS; KAPPA-B; NUCLEAR FACTOR; PHORBOL ESTERS; LYMPHOCYTES-B; HELPER LYMPHOCYTES; BINDING PROTEINS; HUMORAL IMMUNITY;
Keywords:
CD40 LIGAND; DNA BINDING PROTEINS; NUCLEOPROTEIN COMPLEXES; PROLIFERATION; PROTEIN KINASE C; SURFACE IG;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
D.A. Francis et al., "INDUCTION OF THE TRANSCRIPTION FACTORS NF-KB, AP-1 AND NF-AT DURING B-CELL STIMULATION THROUGH THE CD40 RECEPTOR", International immunology, 7(2), 1995, pp. 151-161

Abstract

To address elements that might uniquely characterize CD40 mediated signaling, the nuclear expression of three transcription factors was evaluated following B cell stimulation by CD40L and by anti-lg antibody, Cross-linked CD40L was found to induce nuclear expression of NF-kappa B, AP-1 and NF-AT with a time course and intensity similar to that produced by anti-lg, Examination of NF-kappa B in more detail demonstrated that the CD40 mediated expression of DNA binding complexes correlated with induction of trans-activating activity which again attained similar levels following cross-linking of CD40 and slg, Despite the marked similarity in transcription factor induction triggered through CD40 and slg, differences in the intracellular signaling pathways utilized were apparent in that protein kinase C (PKC) depletion did not affect CD40 mediated induction of NF-kappa B even as induction by anti-lg wasabolished, These results suggest that a 'final common pathway' or convergence of transcription factor induction may exist for two distinct receptors, each of which is individually capable of triggering cell cycle progression, despite the use of separate intracellular signaling pathways that differ at the level of PKC. Although transcription factorinduction was similar for CD40L and anti-lg early on, subtle differences in expressed NF-kappa B and AP-1 nucleoprotein complexes were apparent at 24 h. Such differences may play a role in determining the variant effects on B cells of stimulation through these two receptors.

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Documento generato il 29/11/20 alle ore 08:56:30