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Titolo:
THE IMPAIRMENT OF LONG-TERM-MEMORY FORMATION BY THE PHOSPHATASE INHIBITOR OKADAIC ACID
Autore:
ZHAO WQ; BENNETT P; SEDMAN GL; NG KT;
Indirizzi:
LA TROBE UNIV,DEPT PSYCHOL BUNDOORA VIC 3083 AUSTRALIA LA TROBE UNIV,DEPT PSYCHOL BUNDOORA VIC 3083 AUSTRALIA
Titolo Testata:
Brain research bulletin
fascicolo: 6, volume: 36, anno: 1995,
pagine: 557 - 561
SICI:
0361-9230(1995)36:6<557:TIOLFB>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE-C; SYNAPTIC PLASTICITY; MAMMALIAN-TISSUES; ION CHANNELS; PHOSPHORYLATION; DEPHOSPHORYLATION; POTENTIATION; DEPRESSION; CALMODULIN; RECEPTORS;
Keywords:
PROTEIN KINASES; PROTEIN PHOSPHATASES; OKADAIC ACID; NEONATE CHICKS; PASSIVE AVOIDANCE LEARNING; INTERMEDIATE MEMORY STAGE; LONG TERM MEMORY STAGE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
W.Q. Zhao et al., "THE IMPAIRMENT OF LONG-TERM-MEMORY FORMATION BY THE PHOSPHATASE INHIBITOR OKADAIC ACID", Brain research bulletin, 36(6), 1995, pp. 557-561

Abstract

While there is considerable evidence that protein kinase activity is involved in memory formation, there has been, as yet, no direct investigation of a role for protein phosphatases. However, phosphatases havebeen implicated in the effects of the activation of glutamate receptors of the NMDA type, in longterm depression, and in the regulation of transmitter release and membrane ion channel activities, phenomena which have been shown to be possibly involved in cellular memorial processes. In the present paper, inhibition of protein phosphatase by 0.5 nMokadaic acid, a selective inhibitor of phosphatases 1 and 2A, is demonstrated to prevent memory consolidation in day-old chicks trained on a single trial passive avoidance task. Retention losses first occurredafter 30 min post-learning, at an intermediate stage of memory formation preceding a protein synthesis-dependent long-term stage. It is suggested that protein phosphatase activity is involved in precursor processes to long-term memory consolidation.

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Documento generato il 06/07/20 alle ore 08:10:22