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Titolo:
CO-STRATIFICATION OF GABA(A) RECEPTORS WITH THE DIRECTIONALLY SELECTIVE CIRCUITRY OF THE RAT RETINA
Autore:
BRANDSTATTER JH; GREFERATH U; EULER T; WASSLE H;
Indirizzi:
MAX PLANCK INST HIRNFORSCH,DEUTSCHORDENSTR 46 D-60528 FRANKFURT GERMANY MAX PLANCK INST HIRNFORSCH D-60528 FRANKFURT GERMANY
Titolo Testata:
Visual neuroscience
fascicolo: 2, volume: 12, anno: 1995,
pagine: 345 - 358
SICI:
0952-5238(1995)12:2<345:COGRWT>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHOLINERGIC AMACRINE CELLS; ACCESSORY OPTIC-SYSTEM; GAMMA-AMINOBUTYRIC-ACID; SUBUNIT MESSENGER-RNAS; RABBIT RETINA; GANGLION-CELLS; MAMMALIAN RETINA; A-RECEPTORS; VERTEBRATE RETINA; IMMUNOCYTOCHEMICAL LOCALIZATION;
Keywords:
GABA(A) RECEPTOR SUBUNITS; CHOLINERGIC AMACRINE CELLS; EXPRESSION OF GLUTAMATE TRANSPORTER GLT-1; LOCALIZATION OF SYNAPTOPORIN; MOLECULAR BASIS OF DIRECTIONAL SELECTIVITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
92
Recensione:
Indirizzi per estratti:
Citazione:
J.H. Brandstatter et al., "CO-STRATIFICATION OF GABA(A) RECEPTORS WITH THE DIRECTIONALLY SELECTIVE CIRCUITRY OF THE RAT RETINA", Visual neuroscience, 12(2), 1995, pp. 345-358

Abstract

Direction-selective (DS) ganglion cells of the mammalian retina have their dendrites in the inner plexiform layer (IPL) confined to two narrow strata. The same strata are also occupied by the dendrites of cholinergic amacrine cells which are probably presynaptic to the DS ganglion cells. GABA is known to play a crucial role in creating DS responses. We examined the types of GABA(A) receptors expressed by the cholinergic amacrine cells and also those expressed by their presynaptic and postsynaptic neurons, by applying immunocytochemical markers to vertical sections of rat retinas. Double-labelling experiments with antibodies against choline acetyltransferase (ChAT) and specific antibodies against different GABA(A) receptor subunits were performed. Cholinergic amacrine cells seem to express an unusual combination of GABA(A) receptor subunits consisting of alpha 2-, beta 1-, beta 2/3-, gamma 2-, anddelta-subunits. Bipolar cells, which could provide synaptic input to the DS circuitry, were stained with antibodies against the glutamate transporter GLT-1. The axon terminals of these bipolar cells are narrowly stratified in close proximity to the dendritic plexus of displaced cholinergic amacrine cells. The retinal distribution of synaptoporin, a synaptic vesicle associated protein, was studied. Strong reduction of immunolabelling was observed in the two cholinergic strata. The anatomical findings are discussed in the context of models of the DS circuitry of the mammalian retina.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/08/20 alle ore 19:26:26