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Titolo:
NEUROKININ-A AFFECTS THE TUBERO-HYPOPHYSEAL GABAERGIC SYSTEM
Autore:
PISERA D; DELAURENTIIS A; DUVILANSKI B; LASAGA M; DIAZ MD; SEILICOVICH A;
Indirizzi:
UNIV BUENOS AIRES,FAC MED,CTR INVEST REPROD RA-1121 BUENOS AIRES DF ARGENTINA
Titolo Testata:
NeuroReport
fascicolo: 13, volume: 7, anno: 1996,
pagine: 2236 - 2240
SICI:
0959-4965(1996)7:13<2236:NATTGS>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROLACTIN SECRETION; SUBSTANCE-P; RELEASE; RAT; GABA; VASOPRESSIN; INVIVO; TACHYKININS; RECEPTORS; OXYTOCIN;
Keywords:
NEUROKININ A; GABA; TACHYKININS; ANTERIOR PITUITARY; NEUROINTERMEDIATE LOBE; MEDIAN EMINENCE; PROLACTIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
D. Pisera et al., "NEUROKININ-A AFFECTS THE TUBERO-HYPOPHYSEAL GABAERGIC SYSTEM", NeuroReport, 7(13), 1996, pp. 2236-2240

Abstract

WE have studied the in vitro effects of neurokinin A (NKA) on anterior pituitary GABA concentration and GABA release from the mediobasal hypothalamus and the neurointermediate lobe of male and ovariectomized female (OVX) rats, NKA significantly decreased the anterior pituitary GABA concentration, while the presence of a specific anti-NKA serum in the incubation medium increased the GABA concentration in this gland. By contrast, NKA did not modify basal or K+-evoked GABA release from the mediobasal hypothalamus of male or OVX rats. However, NKA decreasedbasal and K+-evoked GABA release from the neurointermediate lobe, Since GABA inhibits both prolactin (PRL) secretion from the anterior pituitary and the release of several putative PRL-releasing factors from the neurointermediate lobe, the decrease in anterior pituitary GABA concentration and the reduction in tubero-hypophyseal GABAergic activity induced by NKA may contribute to the stimulatory effect of this peptide on PRL secretion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 22:20:14