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Titolo:
EFFECT OF THE AMPA RECEPTOR MODULATOR IDRA-21 ON LTP IN HIPPOCAMPAL SLICES
Autore:
ARAI A; GUIDOTTI A; COSTA E; LYNCH G;
Indirizzi:
UNIV CALIF IRVINE,CTR NEUROBIOL LEARNING & MEMORY IRVINE CA 92697 UNIV ILLINOIS,INST PSYCHIAT CHICAGO IL 60612
Titolo Testata:
NeuroReport
fascicolo: 13, volume: 7, anno: 1996,
pagine: 2211 - 2215
SICI:
0959-4965(1996)7:13<2211:EOTARM>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
S,S-DIOXIDE IDRA-21; RAT HIPPOCAMPUS; POTENTIATION; DESENSITIZATION; CYCLOTHIAZIDE; STIMULATION; DIAZOXIDE; INDUCTION; CURRENTS; ACID;
Keywords:
ORO-3-METHYL-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE S,S-DIOXIDE; AMPA RECEPTOR; CA1; PYRAMIDAL NEURONS; NOOTROPIC; FEEDFORWARD IPSPS; EPSPS; LONG-TERM POTENTIATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
A. Arai et al., "EFFECT OF THE AMPA RECEPTOR MODULATOR IDRA-21 ON LTP IN HIPPOCAMPAL SLICES", NeuroReport, 7(13), 1996, pp. 2211-2215

Abstract

IDRA 21 oro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine S,S-dioxide) has been reported to modulate AMPA receptor kinetics and to improvememory in certain animal models. In the present study, its effects onsynaptic transmission and long-term potentiation (LTP) were tested inhippocampal slices. IDRA 21 (500 mu M) significantly increased the amplitude and halfwidth of field EPSPs. The drug did not affect monosynaptic IPSPs but enhanced disynaptically-induced feedforward IPSPs, presumably by acting on AMPA receptors on interneurons. At concentrations that facilitated synaptic transmission, IDRA 21 promoted the inductionof LTP; i.e. full potentiation was obtained with stimulation paradigms that were only partially effective in the absence of drug. The results support the hypothesis that drugs which enhance AMPA receptor-mediated currents facilitate LTP.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 18:17:49