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Titolo:
EXPRESSION OF GH, TSH-BETA, LH-BETA AND FSH-BETA GENES DURING FETAL PITUITARY DEVELOPMENT IN THE PIG
Autore:
MA E; KLEMPT N; GROSSMANN R; IVELL R; KATO Y; ELLENDORFF F;
Indirizzi:
INST KLEINTIERFORSCH,DORNBERGSTR 25-27 D-29223 CELLE GERMANY INST KLEINTIERFORSCH D-29223 CELLE GERMANY INST ANIM SCI & ANIM BEHAV FAL NEUSTADT GERMANY INST HORMONE & FERTIL RES D-2000 HAMBURG GERMANY GUNMA UNIV,INST ENDOCRINOL GUNMA JAPAN
Titolo Testata:
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
fascicolo: 6, volume: 104, anno: 1996,
pagine: 464 - 472
SICI:
0947-7349(1996)104:6<464:EOGTLA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT ANTERIOR-PITUITARY; PORCINE GROWTH-HORMONE; DNA-SEQUENCE ANALYSIS; SECRETORY PATTERNS; MOLECULAR-CLONING; CELLS; ONTOGENY; FETUS; SUBUNIT; CDNA;
Keywords:
PIG PITUITARY; IN SITU HYBRIDIZATION; ADENOHYPOPHYSEAL HORMONES; ONTOGENY; DEVELOPMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
E. Ma et al., "EXPRESSION OF GH, TSH-BETA, LH-BETA AND FSH-BETA GENES DURING FETAL PITUITARY DEVELOPMENT IN THE PIG", EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES, 104(6), 1996, pp. 464-472

Abstract

The development of the anterior pituitary gland involves the proliferation and differentiation of ectodermal cells in Rathke's pouch to generate distinct cell types, each of which produces its corresponding trophic hormone. Studying pituitary development will therefore reveal novel aspects of organogenesis. In the present study, we examined by in situ hybridization the expression of genes for anterior pituitary hormones during development of the fetal pig pituitary. We found that the beta-subunit gene of thyroid-stimulating hormone (TSH beta) was first expressed at E40, (E = day of embryonal/fetal life), growth hormone (GH) mRNA appeared between E40 and E50, and the gonadotrophin genes (LH beta and FSH beta) were expressed at E50. The transcripts for TSH beta, LH beta and FSH beta were abundantly expressed at about E80, while GH mRNA continued to be richly expressed until after birth. The GH genewas first expressed in the mantle layer of the anterior lobe, while the TSH beta and gonadotrophin (LH beta and FSH beta) mRNAs were found in the central and the basal regions of the anterior lobe, respectively. All of these mRNAs (GH, TSH beta, LH beta, and FSH beta) remained concentrated until the end of gestation in the area where they first appeared. The distinctive pattern of developmental expression of these hormone genes in the fetal pig anterior pituitary makes this tissue an excellent system in which to study tissue-specific gene activation andregulation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 06:49:27