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Titolo:
INFLUENCE OF CORONA SURFACE-TREATMENT ON THE PROPERTIES OF AN ARTIFICIAL MEMBRANE USED FOR LANGERHANS ISLETS ENCAPSULATION - PERMEABILITY AND BIOCOMPATIBILITY STUDIES
Autore:
KESSLER L; LEGEAY G; JESSER C; DAMGE C; PINGET M;
Indirizzi:
HOP UNIV STRASBOURG,SERV ENDOCRINOL,PAVILLON LERICHE F-67091 STRASBOURG FRANCE UNIV STRASBOURG 1,JEUNE EQUIPE MED STRASBOURG FRANCE IRAP,CTR TRANSFERT TECHNOL,DEPT MAT LE MANS FRANCE INSERM,U61 F-67200 STRASBOURG FRANCE
Titolo Testata:
Biomaterials
fascicolo: 3, volume: 16, anno: 1995,
pagine: 185 - 191
SICI:
0142-9612(1995)16:3<185:IOCSOT>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
BIOARTIFICIAL PANCREAS; POLYPROPYLENE FILM; DIFFUSION-CHAMBERS; TRANSPLANTATION; INVITRO; RATS; DISCHARGE; AIR;
Keywords:
SURFACE TREATMENT; ARTIFICIAL MEMBRANE; PANCREATIC ISLET; INSULIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
L. Kessler et al., "INFLUENCE OF CORONA SURFACE-TREATMENT ON THE PROPERTIES OF AN ARTIFICIAL MEMBRANE USED FOR LANGERHANS ISLETS ENCAPSULATION - PERMEABILITY AND BIOCOMPATIBILITY STUDIES", Biomaterials, 16(3), 1995, pp. 185-191

Abstract

An artificial membrane (AN69 Hospal) suitable for pancreatic islets encapsulation was submitted to a physicochemical treatment (corona discharge) to improve its insulin permeability. This effect depends on theduration of the electrical discharge (expressed as the speed of a conveyor belt) and the distance between the electrodes and the membrane. Among the various treatments tested, the most efficient (distance of 5cm and a speed of 2 cm s(-1)) produced a three-fold increase in insulin diffusion. This improvement persisted after a protein-coating test which mimics in vivo conditions. At 1y after the peritoneal implantation, the corona-treated membrane remained biocompatible. Thus, corona discharge treatment may serve to optimize the properties of artificial membranes used for pancreatic islets encapsulation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 04:21:49