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Titolo:
HIGH IL-4 PRODUCTION IS A STABLE PHENOTYPE OF CD8(NEG)CD45RA(NEG)CD27(NEG) T-CELLS
Autore:
SUNDERPLASSMANN R; MAJDIC O; KNAPP W; HOLTER W;
Indirizzi:
UNIV VIENNA,VIENNA INT RES COOPERAT CTR,INST IMMUNOL,WAEHRINGER GUERTEL 18 VIENNA AUSTRIA UNIV VIENNA,INST IMMUNOL VIENNA AUSTRIA
Titolo Testata:
Cellular immunology
fascicolo: 2, volume: 160, anno: 1995,
pagine: 309 - 313
SICI:
0008-8749(1995)160:2<309:HIPIAS>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN MONONUCLEAR-CELLS; MESSENGER-RNA LEVELS; ACTIVATION ANTIGEN; LYMPHOCYTES-T; HUMAN TH1; CD27; EXPRESSION; STIMULUS; SUBSET; INVIVO;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
R. Sunderplassmann et al., "HIGH IL-4 PRODUCTION IS A STABLE PHENOTYPE OF CD8(NEG)CD45RA(NEG)CD27(NEG) T-CELLS", Cellular immunology, 160(2), 1995, pp. 309-313

Abstract

CD27(neg) T cells are found only among CD4(pos)-CD45RO(pos) T cells and represent a T cell subset functionally distinct from CD27(pos) T cells. We examined CD4(pos)CD45RO(pos) T cells that were sorted into CD27(nep) and CD27(pos) populations for their cytokine production in response to different activation pathways. We found that CD27(neg) T cellsare characterized by high IL-4 and low IL-2 production, regardless ofwhether the cells were activated through CD3 plus CD28, CD2 plus CD28, or PHA plus PMA. However, subpopulation-specific patterns of cytokines were the dearest demonstrable following CD2 plus CD28 stimulation. We conclude from these data that high IL-4 production is a stable phenotype of CD27(neg) T cells. (C) 1995 Academic Press, Inc.

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Documento generato il 26/09/20 alle ore 05:23:57