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Titolo:
CARCINOGENICITY OF POLICOSANOL IN SPRAGUE-DAWLEY RATS - A 24-MONTH STUDY
Autore:
ALEMAN CL; FERREIRO RM; PUIG MN; GUERRA IR; ORTEGA CH; CAPOTE A;
Indirizzi:
NATL CTR SCI RES,CTR NAT PROD,AVE 25 & 158 ST CUBANACAN HAVANA 6880 CUBA
Titolo Testata:
Teratogenesis, carcinogenesis, and mutagenesis
fascicolo: 5, volume: 14, anno: 1994,
pagine: 239 - 249
SICI:
0270-3211(1994)14:5<239:COPISR>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Keywords:
ATEROMIXOL; CARCINOGENICITY; CHOLESTEROL-LOWERING DRUG; HIGHER ALIPHATIC ALCOHOLS; TYPE II HYPERLIPOPROTEINEMIA; SPRAGUE DAWLEY RATS; SUGAR CANE WAX; POLICOSANOL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
C.L. Aleman et al., "CARCINOGENICITY OF POLICOSANOL IN SPRAGUE-DAWLEY RATS - A 24-MONTH STUDY", Teratogenesis, carcinogenesis, and mutagenesis, 14(5), 1994, pp. 239-249

Abstract

The effects of policosanol (50-500 mg/kg) administered orally for 24 months to Sprague Dawley rats of both sexes were investigated. No differences related to daily clinical observations, weight gain, food consumption, or mortality (survival analysis) between groups were found. Histopathological study showed that the frequency of the occurrence of non-neoplastic and neoplastic (benign and malignant) lesions was similar in the control and policosanol-treated groups. The lesions observedin this study were similar to the spontaneous lesions reported in this species in previous studies. Since no drug-related increase in the occurrence of malignant or benign neoplasms was found, nor accelerationin tumors growth in any specific group was observed, this study showsno evidence of policosanol induced carcinogenicity in this strain of rats. (C) 1994 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 07:04:21