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Titolo:
EFFECT OF DIETARY RETINYL PALMITATE ON THE PROMOTION OF ALTERED HEPATIC FOCI BY 3,3',4,4'-TETRACHLOROBIPHENYL AND 2,2',4,4',5,5'-HEXACHLOROBIPHENYL IN RATS INITIATED WITH DIETHYLNITROSAMINE
Autore:
BERBERIAN I; CHEN LC; ROBINSON FR; GLAUERT HP; CHOW CK; ROBERTSON LW;
Indirizzi:
UNIV KENTUCKY,GRAD CTR TOXICOL LEXINGTON KY 40506 UNIV KENTUCKY,GRAD CTR TOXICOL LEXINGTON KY 40506 UNIV KENTUCKY,DEPT FOOD SCI & NUTR LEXINGTON KY 40506 PURDUE UNIV,DEPT PATHOL W LAFAYETTE IN 47907
Titolo Testata:
Carcinogenesis
fascicolo: 2, volume: 16, anno: 1995,
pagine: 393 - 398
SICI:
0143-3334(1995)16:2<393:EODRPO>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
VITAMIN-A; POLYCHLORINATED-BIPHENYLS; POLYBROMINATED BIPHENYLS; TUMOR PROMOTION; QUANTITATIVE STEREOLOGY; LIVER; 3,4,3',4'-TETRACHLOROBIPHENYL; HEPATOCARCINOGENESIS; INDUCTION; RETINOIDS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
I. Berberian et al., "EFFECT OF DIETARY RETINYL PALMITATE ON THE PROMOTION OF ALTERED HEPATIC FOCI BY 3,3',4,4'-TETRACHLOROBIPHENYL AND 2,2',4,4',5,5'-HEXACHLOROBIPHENYL IN RATS INITIATED WITH DIETHYLNITROSAMINE", Carcinogenesis, 16(2), 1995, pp. 393-398

Abstract

The purpose of this study was to determine the effects of dietary vitamin A on the tumor promoting effect of 3,3',4,4'-TCB and 2,2',4,4',5,5'-HCB in a two-stage rat hepatocarcinogeneis model with diethylnitrosamine (DEN, 150 mg/kg) as the initiator. Two weeks after DEN injectionrats were fed a purified diet containing either 2000 or 100 000 IU ofvitamin A in the form of retinyl palmitate. Rats received four biweekly injections of 3,3',4,4'-TCB, 2,2',4,4',5,5'-HCB (300 mu mol/kg), orboth (150 mu mol/kg each) in corn oil (10 ml/kg) for 8 weeks. Controlanimals received vehicle only. Six rats in each group that received no HEN treatment were used as additional control animals. Ten days after the last injection the rats were killed. In rats fed the low retinylpalmitate diet, treatment with 3,3',4,4'-TCB, 2,2',4,4',5,5'-HCB or both compounds lowered hepatic retinyl palmitate content. This effect was prevented by high dietary retinyl palmitate supplementation in ratstreated with 2,2',4,4',5,5'-HCB, but not 3,3',4,4'-TCB or both compounds together. Histopathological examination of the liver showed that high dietary retinyl palmitate lessened the severity of hepatocellular necrosis and fatty changes induced by 3,3',4,4'-TCB alone or in combination with 2,2',4,4',5,5'-HCB. The latter did not cause significant pathological lesions to the liver. However, high dietary retinyl palmitate was not able to prevent thymic involution caused by 3,3',4,4'-TCB. The number and volume of altered hepatic foci were increased by 2,2',4,4',5,5'-HCB and particularly 3,3',4,4'-TCB; no synergistic effect wasseen. Supplementation with high dietary retinyl palmitate diminished the number and volume of foci. These results show that supplementationwith high dietary retinyl palmitate protects against hepatocellular necrosis, fatty changes, and preneoplastic changes induced by 3,3',4,4'-TCB as well as against preneoplastic changes induced by 2,2',4,4',5,5'-HCB. In addition, these two agents did not synergistically induce preneoplastic changes in DEN-induced rats.

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Documento generato il 03/12/20 alle ore 15:54:32