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Titolo:
FUNCTIONAL REPAIR OF STRIATAL SYSTEMS BY NEURAL TRANSPLANTS - EVIDENCE FOR CIRCUIT RECONSTRUCTION
Autore:
DUNNETT SB;
Indirizzi:
UNIV CAMBRIDGE,DEPT EXPTL PSYCHOL,DOWNING ST CAMBRIDGE CB2 3EB ENGLAND UNIV CAMBRIDGE,MRC,CAMBRIDGE CTR BRAIN REPAIR CAMBRIDGE CB2 3EB ENGLAND
Titolo Testata:
Behavioural brain research
fascicolo: 1-2, volume: 66, anno: 1995,
pagine: 133 - 142
SICI:
0166-4328(1995)66:1-2<133:FROSSB>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADRENAL-MEDULLA GRAFTS; ACID-LESIONED STRIATUM; UNILATERAL NEOSTRIATAL LESIONS; ELECTRON-MICROSCOPIC ANALYSIS; NIGRAL DOPAMINE NEURONS; BASAL GANGLIA; BEHAVIORAL RECOVERY; COMPARTMENTAL ORGANIZATION; PARKINSONS-DISEASE; RAT-BRAIN;
Keywords:
NEURAL TRANSPLANTATION; STRIATAL GRAFT; NIGRAL GRAFT; ADRENAL GRAFT; NEOSTRIATUM; CORTICO STRIATAL LOOP; FUNCTIONAL RECOVERY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
101
Recensione:
Indirizzi per estratti:
Citazione:
S.B. Dunnett, "FUNCTIONAL REPAIR OF STRIATAL SYSTEMS BY NEURAL TRANSPLANTS - EVIDENCE FOR CIRCUIT RECONSTRUCTION", Behavioural brain research, 66(1-2), 1995, pp. 133-142

Abstract

Intrastriatal grafts of nigral and adrenal tissues have been found tobe effective in alleviating many of the simple motor and sensorimotordeficits associated with lesions of the nigrostriatal dopamine system. However, the mechanisms by which such grafts exert their effects maybe less specific than originally conceived, and both pharmacological and trophic actions play an essential role. Damage to intrinsic cortico-striatal circuits are unlikely to prove similarly amenable to such diffuse mechanisms of repair. Nevertheless, striatal grafts have been found to alleviate cognitive and motor deficits after excitotoxic lesions of the neostriatum. Accumulating evidence suggests that in this particular case many aspects of functional recovery may indeed be attributable to the striatal grafts providing an effective functional reconstruction of damaged neuronal circuits within the host brain.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 19:08:52