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Titolo:
THE ROLE OF NEUROPEPTIDES IN LEARNING - FOCUS ON THE NEUROKININ SUBSTANCE-P
Autore:
HUSTON JP; HASENOHRL RU;
Indirizzi:
UNIV DUSSELDORF,INST PHYSIOL PSYCHOL 1,UNIV STR 1 D-40225 DUSSELDORF GERMANY UNIV DUSSELDORF,BIOL MED FORSCHUNGSZENTRUM D-40225 DUSSELDORF GERMANY
Titolo Testata:
Behavioural brain research
fascicolo: 1-2, volume: 66, anno: 1995,
pagine: 117 - 127
SICI:
0166-4328(1995)66:1-2<117:TRONIL>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEUS BASALIS MAGNOCELLULARIS; CENTRAL NERVOUS-SYSTEM; CONDITIONED PLACE PREFERENCE; N-TERMINAL SEQUENCE; INHIBITORY AVOIDANCE; DOPAMINE RELEASE; REINFORCING PROPERTIES; AGED RATS; 6-HYDROXYDOPAMINE LESION; REGULATORY MECHANISMS;
Keywords:
MEMORY; REINFORCEMENT; TACHYKININ; SUBSTANCE P FRAGMENTS; NUCLEUS BASALIS MAGNOCELLULARIS; DOPAMINE; NEOSTRIATUM; NUCLEUS ACCUMBENS; IN VIVO MICRODIALYSIS; NEURODEGENERATION; AGING; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
90
Recensione:
Indirizzi per estratti:
Citazione:
J.P. Huston e R.U. Hasenohrl, "THE ROLE OF NEUROPEPTIDES IN LEARNING - FOCUS ON THE NEUROKININ SUBSTANCE-P", Behavioural brain research, 66(1-2), 1995, pp. 117-127

Abstract

The neurokinin substance P (SP) can have neurotrophic as well as memory-promoting effects. The study of its mechanisms may provide new insights into processes underlying learning and neurodegenerative disorders. Our work shows that SP, when applied peripherally (i.p.), promotes memory and is reinforcing at the same dose of 37 nmol/kg. Most important, however, is the finding that these effects seemed to be encoded bydifferent SP-sequences, since the N-terminal SP1-7 (185 nmol/kg) enhanced memory, whereas C-terminal hepta- and hexapeptide sequences of SPproved to be reinforcing in a dose equimolar to SP. These differential behavioral effects were paralleled by selective and site-specific changes in dopamine (DA) activity, as both SP and its C-, but not N-terminus, increased extracellular DA in the nucleus accumbens (NAc), but not in the neostriatum. The neurochemical changes lasted at least 2 h after injection. Direct application of SP (0.74 pmol) into the region of the nucleus basalis magnocellularis (NBM) was also memory-promoting and reinforcing, and again, these effects were differentially producedby the N-terminus and C-terminus, supporting the proposed structure-activity relationship for SP's effects on memory and reinforcement. In addition, it was found that a single injection of SP into the NBM led to an increase of extracellular DA in the contralateral NAc. This effect of SP was observed only in those animals where SP was reinforcing, providing evidence for a lateralized relationship between reinforcement induced by injection of SP into the NBM and DA. activity in the NAc. Furthermore, the outcome of a series of experiments suggests, that SPmay not only be considered to have memory-promoting effects in normalanimals, but can also improve functional recovery after unilateral 6-OHDA lesion of the substantia nigra and after lesions of the hippocampus, and can counteract age-related performance deficits.

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Documento generato il 04/06/20 alle ore 00:32:19