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Titolo:
THYROID-CANCER AFTER EXPOSURE TO EXTERNAL RADIATION - A POOLED ANALYSIS OF 7 STUDIES
Autore:
RON E; LUBIN JH; SHORE RE; MABUCHI K; MODAN B; POTTERN LM; SCHNEIDER AB; TUCKER MA; BOICE JD;
Indirizzi:
NCI,EPIDEMIOL & BIOSTAT PROGRAM BETHESDA MD 20892 NYU,MED CTR,DEPT ENVIRONM MED NEW YORK NY 10010 RADIAT EFFECTS RES FDN,DEPT EPIDEMIOL HIROSHIMA 732 JAPAN RADIAT EFFECTS RES FDN,DEPT EPIDEMIOL PATHOL HIROSHIMA 732 JAPAN CHAIM SHEBA MED CTR,DEPT CLIN EPIDEMIOL IL-52621 TEL HASHOMER ISRAEL UNIV ILLINOIS,MICHAEL REESE HOSP & MED CTR,DEPT ENDOCRINOL & METAB CHICAGO IL 60616
Titolo Testata:
Radiation research
fascicolo: 3, volume: 141, anno: 1995,
pagine: 259 - 277
SICI:
0033-7587(1995)141:3<259:TAETER>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHILDHOOD IRRADIATION; RETROSPECTIVE COHORT; NECK IRRADIATION; SKIN HEMANGIOMA; TINEA CAPITIS; THYMUS GLAND; INDUCED HEAD; FOLLOW-UP; TUMORS; RADIOTHERAPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
56
Recensione:
Indirizzi per estratti:
Citazione:
E. Ron et al., "THYROID-CANCER AFTER EXPOSURE TO EXTERNAL RADIATION - A POOLED ANALYSIS OF 7 STUDIES", Radiation research, 141(3), 1995, pp. 259-277

Abstract

The thyroid gland of children is especially vulnerable to the carcinogenic action of ionizing radiation. To provide insights into various modifying influences on risk, seven major studies with organ doses to individual subjects were evaluated. Five cohort studies (atomic bomb survivors, children treated for tinea capitis, two studies of children irradiated for enlarged tonsils, and infants irradiated for an enlargedthymus gland) and two case-control studies (patients with cervical cancer and childhood cancer) were studied. The combined studies include almost 120,000 people (approximately 58,000 exposed to a wide range ofdoses and 61,000 nonexposed subjects), nearly 700 thyroid cancers and3,000,000 person years of follow-up. For persons exposed to radiationbefore age 15 years, linearity best described the dose response, evendown to 0.10 Gy. At the highest doses (greater than or equal to 10 Gy), associated with cancer therapy, there appeared to be a decrease or leveling of risk. For childhood exposures, the pooled excess relative risk per Gy (ERR/Gy) was 7.7 (95% CI = 2.1, 28.7) and the excess absolute risk per 10(4) PY Gy (EAR/10(4) PY Gy) was 4.4 (95% CI = 1.9, 10.1). The attributable risk percent (AR%) at 1 Gy was 88%. However, thesesummary estimates were affected strongly by age at exposure even within this limited age range. The ERR was greater (P = 0.07) for females than males, but the findings from the individual studies were not consistent. The EAR was higher among women, reflecting their higher rate of naturally occurring thyroid cancer. The distribution of ERR over time followed neither a simple multiplicative nor an additive pattern in relation to background occurrence. Only two cases were seen within 5 years of exposure. The ERR began to decline about 30 years after exposure but was still elevated at 40 years. Risk also decreased significantly with increasing age at exposure, with little risk apparent after age 20 years. Based on limited data, there was a suggestion that spreading dose over time (from a few days to > 1 year) may lower risk, possibly due to the opportunity for cellular repair mechanisms to operate. The thyroid gland in children has one of the highest risk coefficients of any organ and is the only tissue with convincing evidence for risk at about 0.10 Gy. (C) 1995 by Radiation Research Society

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Documento generato il 10/07/20 alle ore 02:10:31