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Titolo:
SIGMA-ANTAGONISTS POTENTIATE OPIOID ANALGESIA IN RATS
Autore:
CHIEN CC; PASTERNAK GW;
Indirizzi:
MEM SLOAN KETTERING CANC CTR,COTZIAS LAB NEUROONCOL,1275 YORK AVE NEWYORK NY 10021 MEM SLOAN KETTERING CANC CTR,COTZIAS LAB NEUROONCOL NEW YORK NY 10021 CORNELL UNIV,COLL MED,DEPT NEUROL ITHACA NY 00000 CORNELL UNIV,COLL MED,DEPT NEUROSCI ITHACA NY 00000 CORNELL UNIV,COLL MED,DEPT PHARMACOL ITHACA NY 00000
Titolo Testata:
Neuroscience letters
fascicolo: 2, volume: 190, anno: 1995,
pagine: 137 - 139
SICI:
0304-3940(1995)190:2<137:SPOAIR>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
NALOXONE BENZOYLHYDRAZONE; BINDING-SITES; RECEPTORS; LIGANDS; BRAIN; SUBTYPES; AFFINITY;
Keywords:
OPIOID ANALGESIA; SIGMA(1) RECEPTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
C.C. Chien e G.W. Pasternak, "SIGMA-ANTAGONISTS POTENTIATE OPIOID ANALGESIA IN RATS", Neuroscience letters, 190(2), 1995, pp. 137-139

Abstract

In mice, activation of sigma(1) receptors antagonizes opioid analgesia. Sigma antagonists potentiate opioid analgesia, implying that the anti-opioid sigma system is tonically active. Go-administration of haloperidol with the mu opioid morphine, the kappa(1) analgesic U50,488H orthe kappa(3) agonist naloxone benzoylhydrazone enhances the analgesicactivity of all agents. The effect results from sigma receptor blockade since (-)sulpiride, a selective D-2 antagonist which does not blocksigma receptors, is inactive.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 18:30:28