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Titolo:
CRITICAL ROLE OF ENDOGENOUS MTV IN ACUTE LETHAL GRAFT-VERSUS-HOST DISEASE
Autore:
MICONNET I; ROGER T; SEMAN M; BRULEYROSSET M;
Indirizzi:
HOP PAUL BROUSSE,INSERM,U267,16 AVE PV COUTURIER F-94800 VILLEJUIF FRANCE UNIV DENIS DIDEROT,IMMUNODIFFERENCIAT LAB PARIS FRANCE
Titolo Testata:
European Journal of Immunology
fascicolo: 2, volume: 25, anno: 1995,
pagine: 364 - 368
SICI:
0014-2980(1995)25:2<364:CROEMI>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
MINOR HISTOCOMPATIBILITY ANTIGENS; T-CELLS; NON-H-2 ANTIGENS; LYMPHOCYTE-T; MICE; PREVENTION; INVITRO; TRANSPLANTATION; IMMUNODOMINANCE; SUPERANTIGENS;
Keywords:
MTV; GRAFT-VERSUS-HOST DISEASE; MINOR HISTOCOMPATIBILITY ANTIGENS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
I. Miconnet et al., "CRITICAL ROLE OF ENDOGENOUS MTV IN ACUTE LETHAL GRAFT-VERSUS-HOST DISEASE", European Journal of Immunology, 25(2), 1995, pp. 364-368

Abstract

Little is known about the etiology of the graft-versus-host disease (GVHD) occuring after transplantation of lymphoid cells incompatible for minor histocompatibility antigens (mHAg). Here, the potential role of host endogenous mouse mammary tumor virus (Mtv)-encoded superantigens (SAg) in the development of lethal GVHD was investigated. In a combination of H-2(d) compatible mice, the presence of Mtv-7 and, to a lesser extent, of Mtv-1, -6, -13 in the host genome, highly increases the rate and severity of GVHD. Kinetic analyses of TCR VP gene expression in recipient mice consistently indicate a dramatic but transient infiltration of GVHD target organs by Mtv-SAg-specific T cells. This suggests that SAg encoded by endogenous Mtv, by activating large T cell subpopulations, would help the response to mHAg and thus play a critical role in the initiation or aggravation of GVHD.

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Documento generato il 28/11/20 alle ore 09:56:41