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Titolo:
LINKED IN-VIVO EXPRESSION OF SOLUBLE INTERLEUKIN-4 RECEPTOR AND INTERLEUKIN-4 IN MURINE SCHISTOSOMIASIS
Autore:
FERNANDEZBOTRAN R; WYNN TA; HIENY S; CASPAR P; CHILTON PM; SHER A;
Indirizzi:
UNIV LOUISVILLE,SCH MED,DEPT PATHOL,DIV IMMUNOPATHOL LOUISVILLE KY 40292 UNIV LOUISVILLE,SCH MED,DEPT MICROBIOL & IMMUNOL LOUISVILLE KY 40292 NIAID,PARASIT DIS LAB,IMMUNOL & CELL BIOL SECT BETHESDA MD 20892
Titolo Testata:
European Journal of Immunology
fascicolo: 3, volume: 25, anno: 1995,
pagine: 649 - 656
SICI:
0014-2980(1995)25:3<649:LIEOSI>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; STIMULATORY FACTOR-I; RESTING B-CELLS; INTERFERON-GAMMA; IL-4 RECEPTOR; T-CELLS; CYTOKINE RECEPTORS; MONOCLONAL-ANTIBODY; PROTECTIVE IMMUNITY; GRANULOMA-FORMATION;
Keywords:
SOLUBLE INTERLEUKIN-4 RECEPTOR; IMMUNOREGULATION; SCHISTOSOMA MANSONI; INTERLEUKIN-4;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
R. Fernandezbotran et al., "LINKED IN-VIVO EXPRESSION OF SOLUBLE INTERLEUKIN-4 RECEPTOR AND INTERLEUKIN-4 IN MURINE SCHISTOSOMIASIS", European Journal of Immunology, 25(3), 1995, pp. 649-656

Abstract

Soluble interleukin-4 receptors (sIL-4R) are truncated IL-4R molecules that are secreted into biological fluids. To gain an insight into the mechanisms that control sIL-4R synthesis in vivo and their role in the regulation of immune responses, the expression and secretion of sIL-4R in mice infected with Schistosoma mansoni was studied. Splenocytesfrom infected animals responded to schistosomal antigen preparations with increased production of both IL-4 and sIL-4R. The synthesis of sIL-4R by spleen cells peaked at 8 weeks following infection and coincided with maximum levels of sIL-4R in serum and sIL-4R-specific mRNA in the liver of infected mice. The expression of IL-4-specific mRNA in the liver was different from that of IL-4R, reaching its peak approximately 2 weeks earlier. A relationship between sIL-4R production and the development and activation of Th2 cells was suggested by the findings that: (a) in vivo administration of anti-IL-4 antibodies (11B11) impaired the ability of splenic cells to secrete either IL-4 or sIL-4R; and(b) splenic cells from mice vaccinated with irradiated cercariae,which tend to develop much weaker Th2 responses than mice injected with live cercariae, expressed reduced levels of sIL-4R when challenged with schistosomal antigens. Moreover, a direct role for IL-4 in regulating the expression of sIL-4R was suggested by the ability of anti-IL-4 antibodies to inhibit sIL-4R synthesis in vitro. These data provide the first evidence demonstrating that the production of sIL-4R in vivo is up-regulated during immune responses, especially during those characterized by the development and activation of Th2 cells and IL-4 secretion. The association between sIL-4R and IL-4 syntheses is consistent witha potential role for sIL-4R in the regulation of IL-4 activity in vivo.

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Documento generato il 28/11/20 alle ore 00:56:43