Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
APOPTOSIS, RETINITIS-PIGMENTOSA, AND DEGENERATION
Autore:
WONG P;
Indirizzi:
NEI,9000 ROCKVILLE PIKE BETHESDA MD 20892
Titolo Testata:
Biochemistry and cell biology
fascicolo: 11-12, volume: 72, anno: 1994,
pagine: 489 - 498
SICI:
0829-8211(1994)72:11-12<489:ARAD>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
INHERITED RETINAL DYSTROPHY; RAT VENTRAL PROSTATE; GANGLION-CELL DEATH; RETE TESTIS FLUID; RD MOUSE RETINAS; SULFATED GLYCOPROTEIN-2; GENE-EXPRESSION; MESSENGER-RNA; BETA-SUBUNIT; DEVELOPMENTAL EXPRESSION;
Keywords:
RETINAL DEGENERATION; APOPTOSIS; RETINITIS PIGMENTOSA; CLUSTERIN; DNA FRAGMENTATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
82
Recensione:
Indirizzi per estratti:
Citazione:
P. Wong, "APOPTOSIS, RETINITIS-PIGMENTOSA, AND DEGENERATION", Biochemistry and cell biology, 72(11-12), 1994, pp. 489-498

Abstract

The mechanism of photoreceptor cell death in different inherited retinal degenerations is not fully understood. Mutations in a number of different genes (such as rhodopsin, the beta subunit of cGMP phosphodiesterase, and peripherin) have been identified as the primary genetic lesion in different forms of human retinitis pigmentosa, one of the mostcommon causes of inherited blindness. In all cases the manifestation of the disorder regardless of the specific primary genetic lesion is similar, resulting in photoreceptor cell degeneration and blindness. A recent hypothesis is that the active photoreceptor cell death, which is characteristic of these genetically distinct disorders, is mediated by a common induction of apoptosis. In the present review, the currentevidence for active cell death during retinal cell death in several different rodent models of retinitis pigmentosa and retinal degeneration is examined.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 14:36:38