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Titolo:
CHOLINERGIC LESIONS BY 192-IGG-SAPORIN AND SHORT-TERM RECOGNITION MEMORY - ROLE OF THE SEPTOHIPPOCAMPAL PROJECTION
Autore:
STECKLER T; KEITH AB; WILEY RG; SAHGAL A;
Indirizzi:
NEWCASTLE GEN HOSP,MRC NEUROVCHEM PATHOL UNIT,WESTGATE RD NEWCASTLE TYNE NE6 4BE TYNE & WEAR ENGLAND VANDERBILT UNIV,DEPT NEUROL NASHVILLE TN 00000 VANDERBILT UNIV,DEPT PHARMACOL NASHVILLE TN 00000 DEPT VET AFFAIRS MED CTR,NEUROL SERV 127 NASHVILLE TN 37212
Titolo Testata:
Neuroscience
fascicolo: 1, volume: 66, anno: 1995,
pagine: 101 - 114
SICI:
0306-4522(1995)66:1<101:CLB1AS>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEUS BASALIS MAGNOCELLULARIS; GROWTH-FACTOR RECEPTOR; WORKING MEMORY; FOREBRAIN LESIONS; NGF RECEPTOR; RATS; SCOPOLAMINE; PERFORMANCE; POSITION; FORNIX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
76
Recensione:
Indirizzi per estratti:
Citazione:
T. Steckler et al., "CHOLINERGIC LESIONS BY 192-IGG-SAPORIN AND SHORT-TERM RECOGNITION MEMORY - ROLE OF THE SEPTOHIPPOCAMPAL PROJECTION", Neuroscience, 66(1), 1995, pp. 101-114

Abstract

Two experiments examined the effects of cholinergic basal forebrain lesions by intraventricular and intrahippocampal infusions of the immunotoxin 192 IgG-saporin on recognition memory in an operant delayed-non-matching-to-position task in rats. Intraventricular infusions produced extensive reductions in cortical and hippocampal choline acetyltransferase activity In the first experiment. Behaviourally, a mixed delay-dependent/independent accuracy deficit and increased biased respondingwas observed post-lesioning. Thus, both mnemonic as well as non-mnemonic processes were affected by the lesion. This performance deficit was indistinguishable from the impairment induced by acute intraventricular injections of the choline uptake inhibitor hemicholinium-3, which suggests that cholinergic damage induced by 192 IgG-saporin disrupted performance, In the second experiment more discrete intrahippocampal 192 IgG-saporin: lesions were made, which reduced hippocampal choline acetyltransferase activity about 57%, although this reduction was not as extensive as following intraventricular injections. Although intrahippocampal lesions also impaired non-matching accuracy, this effect failed to reach significance during most stages of the experiment. Scopolamine just failed to significantly impair (P = 0.053) performance in hippocampal lesioned rats more than in controls. The nicotinic antagonist mecamylamine did not affect the lesion-induced changes in performance. These results suggest that the cholinergic basal forebrain, including the septohippocampal system, is important for the mediation of recognition memory, and muscarinic receptor-mediated mechanisms may be ofgreater importance than alterations pf nicotinic receptor-mediated processes in the septohippocampal system.

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Documento generato il 30/03/20 alle ore 18:43:28