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Titolo:
SPONTANEOUS CARDIAC BAROREFLEX IN HUMANS - COMPARISON WITH DRUG-INDUCED RESPONSES
Autore:
PARLOW J; VIALE JP; ANNAT G; HUGHSON R; QUINTIN L;
Indirizzi:
FAC MED GRANGE BLANCHE,ENVIRONM PHYSIOL LAB,CNRS,SDI 6100 F-69373 LYON 08 FRANCE FAC MED GRANGE BLANCHE,ENVIRONM PHYSIOL LAB,CNRS,SDI 6100 F-69373 LYON 08 FRANCE FAC MED GRANGE BLANCHE,ENVIRONM PHYSIOL LAB,CNRS,URA 1341 F-69373 LYON 08 FRANCE FAC MED GRANGE BLANCHE,DEPT ANESTHESIE F-69373 LYON 08 FRANCE UNIV WATERLOO,DEPT KINESIOL WATERLOO ON N2L 3G1 CANADA
Titolo Testata:
Hypertension
fascicolo: 5, volume: 25, anno: 1995,
pagine: 1058 - 1068
SICI:
0194-911X(1995)25:5<1058:SCBIH->2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEART-RATE REFLEX; BLOOD-PRESSURE; ESSENTIAL-HYPERTENSION; BARORECEPTOR REFLEX; CAROTID BAROREFLEX; ARTERIAL-PRESSURE; SENSITIVITY; CLONIDINE; VAGAL; GAIN;
Keywords:
PRESSORECEPTORS; BLOOD PRESSURE; HEART RATE; AUTONOMIC NERVOUS SYSTEM; CLONIDINE; ATROPINE; PROPRANOLOL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
J. Parlow et al., "SPONTANEOUS CARDIAC BAROREFLEX IN HUMANS - COMPARISON WITH DRUG-INDUCED RESPONSES", Hypertension, 25(5), 1995, pp. 1058-1068

Abstract

We compared two methods of assessment of baroreflex sensitivity in eight supine healthy volunteers during repeated baseline measurements and various conditions of cardiac autonomic blockade. The spontaneous baroreflex method involved computer scanning of recordings of continuousfinger arterial pressure and electrocardiogram to locate sequences ofthree or more beats in which pressure spontaneously increased or decreased, with parallel changes in pulse intervals. The mean regression slope of all these sequences during each study condition was consideredto represent the mean spontaneous baroreflex slope. In the drug-induced method, sigmoidal curves were constructed from data obtained by bolus injections of phenylephrine and nitroprusside; the tangents taken at the resting pressure of each of these curves were compared with the mean spontaneous baroreflex slopes. The two methods yielded slopes that were highly correlated (r=.96, P<.001), with significant but similarintraindividual baseline variability. Atropine virtually eliminated the baroreflex slope; subsequent addition of propranolol did not alter it further. Propranolol or clonidine alone increased average baroreflex slope to the extent that they increased resting pulse interval (r=.69 to .83). The spontaneous baroreflex method provides a reliable, noninvasive assessment of human vagal cardiac baroreflex sensitivity within its physiological operating range.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 12:47:05