Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
PRIMING OF A D-1 DOPAMINE-RECEPTOR BEHAVIORAL-RESPONSE IS DISSOCIATEDFROM STRIATAL IMMEDIATE-EARLY GENE ACTIVITY
Autore:
PAUL ML; CURRIE RW; ROBERTSON HA;
Indirizzi:
DALHOUSIE UNIV,DEPT PHARMACOL,MOLEC NEUROBIOL LAB HALIFAX NS B3H 4H7 CANADA DALHOUSIE UNIV,DEPT PHARMACOL,MOLEC NEUROBIOL LAB HALIFAX NS B3H 4H7 CANADA DALHOUSIE UNIV,DEPT ANAT HALIFAX NS B3H 4H7 CANADA DALHOUSIE UNIV,DEPT NEUROBIOL HALIFAX NS B3H 4H7 CANADA
Titolo Testata:
Neuroscience
fascicolo: 2, volume: 66, anno: 1995,
pagine: 347 - 359
SICI:
0306-4522(1995)66:2<347:POADDB>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
C-FOS EXPRESSION; NEONATAL 6-OHDA-LESIONED RATS; NUCLEUS-ACCUMBENS; BASAL GANGLIA; STRIATOPALLIDAL NEURONS; MOLECULAR MECHANISMS; ROTATIONAL BEHAVIOR; NERVOUS-SYSTEM; COCAINE; AMPHETAMINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
68
Recensione:
Indirizzi per estratti:
Citazione:
M.L. Paul et al., "PRIMING OF A D-1 DOPAMINE-RECEPTOR BEHAVIORAL-RESPONSE IS DISSOCIATEDFROM STRIATAL IMMEDIATE-EARLY GENE ACTIVITY", Neuroscience, 66(2), 1995, pp. 347-359

Abstract

Repeated administration of direct-acting (apomorphine, SKF-38393, quinpirole) or indirect-acting (amphetamine, cocaine) dopaminergic agonists can produce enhancement of locomotor and sterotypic behaviours in response to subsequent dopamine agonist challenge. This sensitization of dopamine receptors, known as priming or reverse tolerance, is long-lasting and appears to be dependent upon the participation of the N-methyl-D-asparate excitatory amino acid receptor. The mechanism underlying dopamine receptor sensitization is not understood. Mounting evidencesuggests that immediate-early genes may provide a link whereby extracellular stimuli are converted into long-term changes in neuronal activity. In the present study, behavioural measurements and immunohistochemical techniques were used to determine whether induction of the immediate-early gene c-Sos is critical to the mechanism underlying priming of a D-1-mediated behavioural response. It was demonstrated that in drug-naive rats bearing unilateral 6-hydroxydopamine lesions of the dopaminergic nigrostriatal pathway, the mixed D-1/D-2 agonist apomorphine produced a dramatic increase in the expression of Fos-like immunoreactivity in the ipsilateral caudoputamen, nucleus accumbens and globus pallidus, and was a potent primer of SKF-38393-mediated rotational behaviour. In contrast, saline administration did not increase Fos expression and did not prime SKF-38393-elicited rotation. Preadministration ofMK-801 at 0.5 mg/kg significantly reduced apomorphine's effect on Fosexpression and prevented apomorphine priming of SKF-38393-induced rotation. However, at a lower dose of 0.1 mg/kg, MK-801 had little effecton apomorphine-mediated Fos expression but did block the priming response. In another experiment, the D-2 family-selective agonist quinpirole was found to be an effective primer of SKF-38393-mediated rotation,and to produce increased Fos expression in the ipsilateral globus pallidus only. Preadministration of MK-801 at 0.1 mg/kg blocked quinpirole priming of SKF-38393-mediated rotation and significantly reduced thenumber of Fos-positive neurons in the ipsilateral globus pallidus. Administration of the indirect dopamine agonist amphetamine increased Fos expression in the intact striatum, but not in the ipsilateral (lesioned) striatum or globus pallidus, acid did not sensitize (prime) animals to behavioural effects of SKF-38393. In a separate group of animals, Northern blot analysis demonstrated that a priming dose of apomorphine significantly increased the messenger RNA signals for c-fos, c-jun,ngfi-A and jun-B in denervated striatum. Administration of 0.1 mg/kg MK-801 prior to apomorphine had no significant effect on signal intensities. Taken together, the results of the present study suggest that priming of D-1-mediated rotational behaviour can occur independent of activation, in striatum, of c-fos and several other immediate-early genes in rats with unilateral 6-hydroxydopamine lesions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 22:07:44