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Titolo:
THE OXYTOCIN RECEPTOR, LUTEOLYSIS AND THE MAINTENANCE OF PREGNANCY
Autore:
WATHES DC; LAMMING GE;
Indirizzi:
UNIV LONDON ROYAL VET COLL,DEPT ANIM HLTH,BOLTONS PK,HAWKSHEAD RD POTTERS BAR EN6 1NB HERTS ENGLAND UNIV NOTTINGHAM,DEPT PHYSIOL & ENVIRONM STUDIES LOUGHBOROUGH LE12 5RDLEICS ENGLAND
Titolo Testata:
Journal of Reproduction and Fertility
, , anno: 1995, supplemento:, 49
pagine: 53 - 67
SICI:
0022-4251(1995):<53:TORLAT>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONCEPTUS SECRETORY PROTEINS; ESTROUS-CYCLE; OVARIECTOMIZED EWES; PROSTAGLANDIN-F2-ALPHA SECRETION; PHOSPHOINOSITIDE HYDROLYSIS; PLASMA-CONCENTRATIONS; LUTEAL CONCENTRATIONS; MATERNAL RECOGNITION; INOSITOL PHOSPHATE; OVINE ENDOMETRIUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
57
Recensione:
Indirizzi per estratti:
Citazione:
D.C. Wathes e G.E. Lamming, "THE OXYTOCIN RECEPTOR, LUTEOLYSIS AND THE MAINTENANCE OF PREGNANCY", Journal of Reproduction and Fertility, 1995, pp. 53-67

Abstract

During luteal regression episodic pulses of oxytocin secretion becomecoupled to the release of prostaglandin F-2 alpha (PGF(2 alpha) following synthesis of endometrial oxytocin receptors, but in early pregnancy the inhibition of oxytocin receptor formation by the conceptus prevents the development of the pulsatile pattern of PGF(2 alpha) release needed to achieve luteolysis. Oxytocin receptors are present on the luminal epithelium in ovariectomized and anoestrous ewes, in pregnant animals throughout most of gestation (day 21 to term) and in explants ofendometrial tissue cultured in vitro. These receptors can be downregulated for a brief period by progesterone (10-12 days in sheep, 12-14 days in cattle). This period of inhibition can be extended by infusion of interferon tau (IFN-tau) (which probably inhibits oxytocin receptorgene transcription) or of oxytocin into the systemic circulation which may act further; downstream, possibly at the level of translation). Oxytocin receptors also develop on the caruncular stroma and deep glands at oestrus, but these need positive upregulation and appear dependent on an oestrogenic environment. Only epithelial receptors are neededto achieve a maximal PGF(2 alpha) response to an oxytocin challenge, but the presence of oxytocin receptors does not necessarily confer responsiveness as other factors may influence intracellular coupling mechanisms and precursor availability. The duration of the luteal phase isregulated by the time of the initial post-ovulatory rise in progesterone and the duration of exposure to progesterone: However, the development of oxytocin receptors in the luminal epithelium is not directly preceded by changes in the concentration of either progesterone or its receptor, implying that an intermediary time-dependent mechanism mediates the inhibitory effect of progesterone on oxytocin receptor formation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 15:47:47