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Titolo:
IMMUNOHISTOCHEMICAL STAINING AND ACTIVITY OF ORNITHINE DECARBOXYLASE IN COLORECTAL-CANCER
Autore:
OYA K; YAMANE T; INAGAKE M; KITAO Y; OKUYAMA A; TAKAHASHI T; IRIE S; NAKAYAMA K; WADAMA K;
Indirizzi:
KYOTO PREFECTURAL UNIV MED,DEPT SURG 1,KAMIKYO KU,KAWARAMACHI HIROKOJI KYOTO 602 JAPAN IDEMITSU KOSAN CO LTD,CENT LAB SODEGAURA CHIBA 29902 JAPAN
Titolo Testata:
Cancer letters
fascicolo: 1, volume: 91, anno: 1995,
pagine: 101 - 106
SICI:
0304-3835(1995)91:1<101:ISAAOO>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOCALIZATION; DNA;
Keywords:
ORNITHINE DECARBOXYLASE (ODC); MONOCLONAL ANTIBODY; IMMUNOHISTOCHEMICAL STAINING; COLORECTAL CANCER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
K. Oya et al., "IMMUNOHISTOCHEMICAL STAINING AND ACTIVITY OF ORNITHINE DECARBOXYLASE IN COLORECTAL-CANCER", Cancer letters, 91(1), 1995, pp. 101-106

Abstract

Using a new anti-human ornithine decarboxylase (anti-hODC) monoclonalantibody, the relationship between the immunoreactivity of ODC and its activity was analyzed in 21 human colorectal cancer tissues, 42 adjacent non-tumorous mucosa specimens, and 10 normal rectal mucosa samples from frozen sections and paraffin-embedded samples. A statistical significant correlation was found between the antibody reaction and the enzymic activity (P < 0.01). The immunohistochemical staining for ODC provides a new and simplified procedure for studying the activity of ODC as compared to previous methods using radioisotopes. It offers the advantages of retrospectively determining the amount of ODC in samplespreviously embedded in paraffin.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/08/20 alle ore 23:00:18