Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
N-RAS MUTATION IN 7,12-DIMETHYLBENZ[A]ANTHRACENE (DMBA)-INDUCED ERYTHROLEUKEMIA IN LONG-EVANS RATS
Autore:
OSAKA M; MATSUO S; KOH T; LIANG P; KINOSHITA H; MAEDA S; SUGIYAMA T;
Indirizzi:
KYOTO UNIV,FAC MED,DEPT PATHOL,SAKYO KU,YOSHIDA KOMOE CHO KYOTO 60601JAPAN KOBE UNIV,SCH MED,DEPT PATHOL,CHUO KU KOBE HYOGO 650 JAPAN
Titolo Testata:
Cancer letters
fascicolo: 1, volume: 91, anno: 1995,
pagine: 25 - 31
SICI:
0304-3835(1995)91:1<25:NMI7(E>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE MYELOID-LEUKEMIA; HA-RAS; GENE-MUTATIONS; MYELODYSPLASTIC SYNDROMES; TUMOR INITIATION; ACTIVATION; ONCOGENES; MOUSE; CARCINOGENESIS; SKIN;
Keywords:
DMBA; LEUKEMIA; N-RAS; CHROMOSOME; RAT; CARCINOGENESIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
M. Osaka et al., "N-RAS MUTATION IN 7,12-DIMETHYLBENZ[A]ANTHRACENE (DMBA)-INDUCED ERYTHROLEUKEMIA IN LONG-EVANS RATS", Cancer letters, 91(1), 1995, pp. 25-31

Abstract

Intravenous injections of 7,12-dimethylbenz[a]anthracene (DMBA) induce erythroblastic leukemia (erythroleukemia) with No.2 trisomy in Long-Evans rats. Activation of some oncogenes such as abl and Ha-ras has been reported to occur in relation to the secondary chromosomal translocations, In the present studies, a consistent type of mutation, A to T transversion in codon 61 of N-ras gene, was found in all of 6 culturedleukemia cell lines and 5 primary leukemias induced by DMBA. The N-ras mutation was also found in bone marrow cells of 2 out of 8 preleukemias. On the contrary, no mutation was observed in Ha- and Ki-ras genesin all leukemias and preleukemias. The consistent occurrence of aboveN-ras mutation in leukemias indicates that it plays an important rolein DMBA-leukemogenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 11:40:22