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Titolo:
HUMAN MUSCLE MACROPHAGES EXPRESS BETA-AMYLOID PRECURSOR AND PRION PROTEINS AND THEIR MESSENGER-RNAS
Autore:
ASKANAS V; SARKOZI E; BILAK M; ALVAREZ RB; ENGEL WK;
Indirizzi:
UNIV SO CALIF,DEPT NEUROL,CTR NEUROMUSCULAR,637 S LUCAS LOS ANGELES CA 90017
Titolo Testata:
NeuroReport
fascicolo: 7, volume: 6, anno: 1995,
pagine: 1045 - 1049
SICI:
0959-4965(1995)6:7<1045:HMMEBP>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
INCLUSION-BODY MYOSITIS; NEUROMUSCULAR-JUNCTIONS; MICROGLIAL CELLS; MESSENGER-RNA; ANTIBODIES; DISEASE; TISSUES;
Keywords:
MACROPHAGES; HUMAN MUSCLE; BETA-APP; BETA-APP MESSENGER-RNA; PRION PROTEIN; PRION PROTEIN MESSENGER-RNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
V. Askanas et al., "HUMAN MUSCLE MACROPHAGES EXPRESS BETA-AMYLOID PRECURSOR AND PRION PROTEINS AND THEIR MESSENGER-RNAS", NeuroReport, 6(7), 1995, pp. 1045-1049

Abstract

WELL-CHARACTERIZED antibodies against beta-amyloid precursor protein (beta APP) and prion protein (PrP), and specific cRNA probes, were used to localize beta APP and PrP and their mRNAs in human muscle macrophages. Macrophages present in muscle biopsies of 51 patients with various neuromuscular disorders showed accumulation of beta APP and PrP, and strongly expressed beta APP and PrP mRNAs. These were present in allmuscle macrophages unrelated to their localization within the muscle tissue or diagnosis. Our study provides the first demonstration that human muscle resident macrophages synthesize and accumulate beta APP and PrP. We suggest that those proteins play a role in biology of musclemacrophages, including their participation in inflammatory and immuneresponses.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 03:26:37