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Titolo:
NIGROSTRIATAL DOPAMINE SYSTEM MEDIATES BAROREFLEX SENSITIVITY IN RATS
Autore:
LU SF; YOUNG HJ; LIN MT;
Indirizzi:
NATL CHENG KUNG UNIV,COLL MED,DEPT PHYSIOL TAINAN 70101 TAIWAN NATL CHENG KUNG UNIV,COLL MED,DEPT PHYSIOL TAINAN 70101 TAIWAN CHIA NAN JR COLL PHARM,DEPT IND SAFETY & HLTH TAINAN TAIWAN
Titolo Testata:
Neuroscience letters
fascicolo: 1, volume: 190, anno: 1995,
pagine: 17 - 20
SICI:
0304-3940(1995)190:1<17:NDSMBS>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
SINOAORTIC-DENERVATED RATS; REFLEX BRADYCARDIA; RELEASE; DISEASE;
Keywords:
DOPAMINE; STRIATUM; BAROREFLEX; VOLTAMMETRY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
S.F. Lu et al., "NIGROSTRIATAL DOPAMINE SYSTEM MEDIATES BAROREFLEX SENSITIVITY IN RATS", Neuroscience letters, 190(1), 1995, pp. 17-20

Abstract

Both sham-operated rats and rats with lesions of the nigrostriatal dopamine (DA) pathway were subjected to increasing or decreasing carotidsinus pressure (respectively produced by phenylephrine injection or bilateral carotid occlusion) and their striatal DA release and baroreflex responses were compared. In sham-operated rats, phenylephrine produced both increased striatal DA release and decreased heart rate, whilebilateral carotid occlusion produced the apposite effects. Both the striatal DA release and baroreflex responses produced by phenylephrine or carotid occlusion were attenuated by lesions of the nigrostriatal DA pathway induced by intra-medial forebrain bundle injection of 6-hydroxydopamine. The data indicate that the nigrostriatal DA pathway mediates baroreflex sensitivity in rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 20:02:24