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Titolo:
ANTIVIRAL ACTION OF OLIGODEOXYGUANYLIC ACIDS AGAINST HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1
Autore:
FUJIHASHI T; SAKATA T; KAJI A; KAJI H;
Indirizzi:
THOMAS JEFFERSON UNIV,DEPT PHARMACOL,1020 LOCUST ST PHILADELPHIA PA 19107 JEFFERSON MED COLL,DEPT PHARMACOL PHILADELPHIA PA 19107 UNIV PENN,SCH MED,DEPT MICROBIOL PHILADELPHIA PA 19104
Titolo Testata:
AIDS research and human retroviruses
fascicolo: 4, volume: 11, anno: 1995,
pagine: 461 - 471
SICI:
0889-2229(1995)11:4<461:AAOOAA>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONICALLY INFECTED-CELLS; AIDS-RELATED COMPLEX; REVERSE-TRANSCRIPTASE; HTLV-III; PHOSPHOROTHIOATE OLIGODEOXYNUCLEOTIDES; NUCLEOTIDE-SEQUENCE; MONOCLONAL-ANTIBODY; COLORIMETRIC ASSAY; VIRAL-RNA; REPLICATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
72
Recensione:
Indirizzi per estratti:
Citazione:
T. Fujihashi et al., "ANTIVIRAL ACTION OF OLIGODEOXYGUANYLIC ACIDS AGAINST HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1", AIDS research and human retroviruses, 11(4), 1995, pp. 461-471

Abstract

Deoxyguanylic acids, but not other deoxynucleotides, as short as 3- to 4-mer, were effective in preventing HIV-1-induced cytopathicity, In addition, they prevented giant cell formation of infected Sup-T1 cells, and p24 production in HIV-1 infected H9 cells, Phosphorylation at either the 5'- or 3'-end enhanced these activities, Furthermore, 5'-phosphorylated phosphorothioate tetradeoxyguanylic acid was effective in reducing HIV production in chronically infected cells (H9/IIIB). The search for the target steps of this compound revealed that it inhibits at least 3 steps in the life cycle of HIV: interaction with CD4 (measured by inhibitory effect on the syncytia formation between Sup-T1 and H9/IIIB cells), reverse transcriptase, and step(s) after integration, These results suggest that phosphorylated phosphorothioate tetradeoxyguanylic acid may be a novel candidate for a therapeutic agent of AIDS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 23:44:49