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Titolo:
INTERACTIONS BETWEEN C-KIT AND STEM-CELL FACTOR ARE NOT REQUIRED FOR B-CELL DEVELOPMENT IN-VIVO
Autore:
TAKEDA S; SHIMIZU T; RODEWALD HR;
Indirizzi:
KYOTO UNIV,SCH MED,BAYER CHAIR DEPT MOL IMMUNOL,SAKYO KU KYOTO 606 JAPAN BASEL INST IMMUNOL BASEL SWITZERLAND
Titolo Testata:
Blood
fascicolo: 2, volume: 89, anno: 1997,
pagine: 518 - 525
SICI:
0006-4971(1997)89:2<518:IBCASF>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEMATOPOIETIC PROGENITOR CELLS; TYROSINE KINASE RECEPTOR; BONE-MARROW; GROWTH-FACTOR; MONOCLONAL-ANTIBODIES; PRECURSOR CELLS; FETAL LIVER; SI-LOCUS; W-LOCUS; MOUSE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
53
Recensione:
Indirizzi per estratti:
Citazione:
S. Takeda et al., "INTERACTIONS BETWEEN C-KIT AND STEM-CELL FACTOR ARE NOT REQUIRED FOR B-CELL DEVELOPMENT IN-VIVO", Blood, 89(2), 1997, pp. 518-525

Abstract

The receptor-type tyrosine kinase, c-kit is expressed in hematopoietic stem cells (HSC), myeloid, and lymphoid precursors. In c-kit ligand-deficient mice, absolute numbers of HSC are mildly reduced suggesting that c-kit is not essential for HSC development However, c-kit(-) HSC cannot form spleen colonies or reconstitute hematopoietic functions inlethally irradiated recipient mice. Based on in in vitro experiments,a critical role of c-kit in B-cell development was suggested. Here wehave investigated the B-cell development of c-kit-null mutant (W/W) mice in vivo. Furthermore, day 13 fetal liver cells from wild type or W/W mice were transferred into immunodeficient RAG-2(-/-) mice. Surprisingly, transferred c-kit(-) cells gave rise to all stages of immature B cells in the bone marrow and subsequently to mature conventional B2,as well as B1, type B cells in the recipients to the same extent as transferred wild type cells. Hence, in contrast to important roles of c-kit in the expansion of HSC and the generation of erythroid and myeloid lineages and T-cell precursors, c-kit- HSC can colonize the recipient bone marrow and differentiate into B cells in the absence of c-kit. (C) 1997 by The American Society of Hematology.

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Documento generato il 27/11/20 alle ore 04:18:32