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Titolo:
DETECTION OF HUMAN HERPESVIRUS-8 AND HUMAN T-CELL LYMPHOTROPIC VIRUS TYPE-1 SEQUENCES IN KAPOSI-SARCOMA
Autore:
LEBBE C; AGBALIKA F; DECREMOUX P; DEPLANCHE M; RYBOJAD M; MASGRAU E; MOREL P; CALVO F;
Indirizzi:
HOP ST LOUIS,POLICLIN DERMATOL,1 AVE C1 VELLEFAUX F-75010 PARIS FRANCE HOP ST LOUIS,DEPT DERMATOL PARIS FRANCE HOP ST LOUIS,PHARMACOL LAB PARIS FRANCE HOP ST LOUIS,VIROL LAB PARIS FRANCE HOP UNIV INTERCANTONAL GENEVE,DEPT DERMATOL GENEVA SWITZERLAND
Titolo Testata:
Archives of dermatology
fascicolo: 1, volume: 133, anno: 1997,
pagine: 25 - 30
SICI:
0003-987X(1997)133:1<25:DOHHAH>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; DNA-SEQUENCES; LEUKEMIA-VIRUS; PERIPHERAL-BLOOD; I INFECTION; AIDS; AMPLIFICATION; CYTOMEGALOVIRUS; IDENTIFICATION; ESTABLISHMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
C. Lebbe et al., "DETECTION OF HUMAN HERPESVIRUS-8 AND HUMAN T-CELL LYMPHOTROPIC VIRUS TYPE-1 SEQUENCES IN KAPOSI-SARCOMA", Archives of dermatology, 133(1), 1997, pp. 25-30

Abstract

Background: Ultrastructural studies have shown retroviral particles in Kaposi sarcoma (KS) unrelated to infection with the human immunodeficiency virus (HIV). Recently, DNA sequences from a new herpesvirus, human herpesvirus 8 (HHV-8), were detected in KS tissues. Objectives: Toscreen for the presence of HHV-8 sequences in patients with KS not related to HIV infection and correlate HHV-8 sequence detection and clinical staging and to screen for the presence of human T-cell lymphotropic virus type 1 (HTLV-1) sequences in the peripheral blood mononuclearcells (PBMCs) of such patients. Design: Tumor and normal skin samplesand PBMCs were investigated by polymerase chain reaction using primers for HHV-8 and HTLV-1 pX gag, pol, and env sequences. Setting: Ambulatory or hospitalized patients from a university hospital associated with a research laboratory. Patients: Thirty-one patients with KS not related to HIV infection (21 classic cases, 3 endemic cases, 1 case associated with Castleman disease, 4 homosexual men, 1 posttransplantationpatient, and 1 patient taking corticosteroids). Stages involved included I (13 patients), II (8 patients), III (7 patients), and IV (3 patients). Results: Human herpesvirus 8 sequences were found in 100% of KSspecimens, 70% of distant normal skin specimens, and 42% of PBMC samples. The percentage of HHV-8 detection in PBMCs was higher in patientswith KS stage III or IV than in patients with stage I or II. Human T-cell lymphotropic virus type I pX sequences were detected in 2 of 19 patients while gag, pol, and env-test results were negative using polymerase chain reaction analysis. Conclusions: Our data suggest no significant association between HTLV-1 infection and KS. Detection of HHV-8 infected cells in normal skin samples from the majority of KS tissues,regardless of clinical staging, can be paralleled to the multifocal pattern of the disease. Human herpesvirus 8 detection in PBMCs could berelated to the tumor burden.

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Documento generato il 02/12/20 alle ore 17:53:15