Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ALTERATIONS IN DIAPHRAGM EMG ACTIVITY DURING OPIATE-INDUCED RESPIRATORY DEPRESSION
Autore:
CAMPBELL C; WEINGER MB; QUINN M;
Indirizzi:
VET ADM MED CTR,125,3350 LA JOLLA VILLAGE DR SAN DIEGO CA 92161 UNIV CALIF SAN DIEGO,DEPT ANESTHESIOL SAN DIEGO CA 92103 VET ADM MED CTR SAN DIEGO CA 92161
Titolo Testata:
Respiration physiology
fascicolo: 2, volume: 100, anno: 1995,
pagine: 107 - 117
SICI:
0034-5687(1995)100:2<107:AIDEAD>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED MUSCULAR RIGIDITY; INDUCED MUSCLE RIGIDITY; RAT; ALFENTANIL; FENTANYL; DEXMEDETOMIDINE; VENTILATION; INVOLVEMENT; INDUCTION;
Keywords:
CONTROL OF BREATHING, OPIATE INDUCED DEPRESSION; MAMMALS, RAT; MEDIATORS, OPIATES; MUSCLE, DIAPHRAGM, INTERCOSTAL; PHARMACOLOGICAL AGENTS; RESPIRATORY MUSCLES, OPIATE INDUCED TONE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
C. Campbell et al., "ALTERATIONS IN DIAPHRAGM EMG ACTIVITY DURING OPIATE-INDUCED RESPIRATORY DEPRESSION", Respiration physiology, 100(2), 1995, pp. 107-117

Abstract

While opiate-induced increases in thoracic muscle tone may contributeto impaired ventilation during opiate anesthesia, the effects of high-dose opiates on diaphragm muscle activity have not been elucidated. The effects of the opiate agonist alfentanil (ALF, 500 mu g/kg subcutaneously) on diaphragm (DIA) and intercostal (IC) electromyographic (EMG) activity in spontaneously ventilating adult rats were studied. EMG segments corresponding to inspiration and expiration were selected using an impedance plethysmographic respiratory waveform. Total EMG activity over a respiratory cycle was significantly greater in the DIA than in the IC. ALF produced a decrease in inspiratory and an increase in expiratory DIA EMG activity. These changes in diaphragm function following ALF were accompanied by significant respiratory depression. The effects of the alpha-2 agonist dexmedetomidine on ALF-induced changes indiaphragm and intercostal EMG activity were also examined, While dexmedetomidine alone had minimal effects on DIA activity, it significantly attenuated the ALF-induced increase in expiratory DIA EMG. The potential etiology and implications of these opiate-induced changes in diaphragm muscle function are discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 10:16:21