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Titolo:
DOPAMINE REGULATION OF TRANSCRIPTION FACTOR-TARGET INTERACTIONS IN RAT STRIATUM
Autore:
HYMAN SE; COLE RL; KONRADI C; KOSOFSKY BE;
Indirizzi:
MASSACHUSETTS GEN HOSP,MOLEC & DEV NEUROSCI LAB,CNY-2,149 13TH ST BOSTON MA 02129 HARVARD UNIV,SCH MED,PROGRAM NEUROSCI BOSTON MA 02115 MASSACHUSETTS GEN HOSP,DEPT PSYCHIAT BOSTON MA 02114 MASSACHUSETTS GEN HOSP,DEPT NEUROL BOSTON MA 02114
Titolo Testata:
Chemical senses
fascicolo: 2, volume: 20, anno: 1995,
pagine: 257 - 260
SICI:
0379-864X(1995)20:2<257:DROTFI>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
C-FOS; CYCLIC-AMP; SOMATOSTATIN GENE; RESPONSE-ELEMENT; COCAINE; PHOSPHORYLATION; EXPRESSION; DYNORPHIN; BINDING; CREB;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
S.E. Hyman et al., "DOPAMINE REGULATION OF TRANSCRIPTION FACTOR-TARGET INTERACTIONS IN RAT STRIATUM", Chemical senses, 20(2), 1995, pp. 257-260

Abstract

Transcriptional regulation is an important mechanism by which neuronsadapt to environmental stimuli. The indirect dopamine agonists, amphetamine and cocaine have been shown to induce expression of immediate early genes, such as c-fos, and neuropeptide genes, such as prodynorphin in the rat striatum. Here we show that phosphorylation of transcription factor CREB is a critical early event coupling dopamine stimulation to gene regulation. CREB interacts with functional regulatory elements in both the c-fos and prodynorphin genes, and is phosphorylated in response to dopamine in a D1 dopamine receptor-dependent manner. In addition, we show by intra-striatal injection of antisense oligonucleotides directed against CREB mRNA, that CREB protein is required for c-fos induction by amphetamine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 09:10:12