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Titolo:
THE IMPORTANCE OF THE KIDNEY IN PRIMARY HYPERTENSION - INSIGHTS FROM CROSS-TRANSPLANTATION
Autore:
RETTIG R; BANDELOW N; PATSCHAN O; KUTTLER B; FREY B; UBER A;
Indirizzi:
UNIV GREIFSWALD,DEPT PHYSIOL,RUBENOWSTR 3 D-17487 GREIFSWALD GERMANY
Titolo Testata:
Journal of human hypertension
fascicolo: 10, volume: 10, anno: 1996,
pagine: 641 - 644
SICI:
0950-9240(1996)10:10<641:TIOTKI>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-PRESSURE; RENAL-TRANSPLANTATION; RATS; HOMOGRAFTS; DONORS;
Keywords:
BLOOD PRESSURE; KIDNEY; PRIMARY HYPERTENSION; SPONTANEOUSLY HYPERTENSIVE RAT; TRANSPLANTATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
R. Rettig et al., "THE IMPORTANCE OF THE KIDNEY IN PRIMARY HYPERTENSION - INSIGHTS FROM CROSS-TRANSPLANTATION", Journal of human hypertension, 10(10), 1996, pp. 641-644

Abstract

Experimental renal cross-transplantation studies with genetically hypertensive and normotensive rats have shown that hypertension travels with the kidney. The underlying mechanisms are currently not well understood. Genetically normotensive recipients of a kidney from spontaneously hypertensive rats show a decreased capacity to excrete sodium whenchallenged with a high-salt diet. Furthermore, they retain more sodium than recipients of a kidney from genetically normotensive donors immediately after transplantation and removal of the native kidneys. Sodium retention precedes hypertension and may contribute to its development. Most recently, it has been shown that bilateral nephrectomy and transplantation of a genetically normotensive kidney attenuates the development of hypertension in young transplanted spontaneously hypertensive rats. Thus, long-term blood pressure in renal transplanted rats is critically determined by the genetic background of the renal graft. Together, these data indicate that genetically determined renal mechanisms play a major role in primary hypertension.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 07:23:43