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Titolo:
NITROGEN TRIFLUORIDE - A NEW REACTANT GAS IN CHEMICAL-REACTION INTERFACE MASS-SPECTROMETRY FOR DETECTION OF PHOSPHORUS, DEUTERIUM, CHLORINE, AND SULFUR
Autore:
SONG HC; ABRAMSON F;
Indirizzi:
GEORGE WASHINGTON UNIV,MED CTR,DEPT PHARMACOL,2300 I ST NW WASHINGTONDC 20037 GEORGE WASHINGTON UNIV,MED CTR,DEPT PHARMACOL WASHINGTON DC 20037
Titolo Testata:
Journal of the American Society for Mass Spectrometry
fascicolo: 5, volume: 6, anno: 1995,
pagine: 421 - 427
SICI:
1044-0305(1995)6:5<421:NT-ANR>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
SELECTIVE DETECTION; ISOTOPE RATIOS; N-15; METABOLITES; C-13;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
H.C. Song e F. Abramson, "NITROGEN TRIFLUORIDE - A NEW REACTANT GAS IN CHEMICAL-REACTION INTERFACE MASS-SPECTROMETRY FOR DETECTION OF PHOSPHORUS, DEUTERIUM, CHLORINE, AND SULFUR", Journal of the American Society for Mass Spectrometry, 6(5), 1995, pp. 421-427

Abstract

A new set of reactions that involve fluorine have been investigated in chemical reaction interface mass spectrometry (CRIMS). The primary goal of this study was to provide a means to selectively detect phosphorus-containing compounds, which fluorine does by generating PF5. PF4+,the main fragment ion of PF5, provides a sensitive (10 pg/s), selective, and linear (> 10(3) dynamic range) channel for phosphorus-containing analytes. This fluorine-rich environment also provides new ways to selectively and simultaneously detect hydrogen isotopes, chlorine, andsulfur. NF3 as a reactant gas provides the most comprehensive array of elemental and isotopic detection yet available for CRIMS. An application of phosphorus-selective detection was attempted by examination ofa plasma sample from a patient who had been treated with cyclophosphamide. The phosphorus-selective channel showed six peaks: one is derivatized phosphate, two are t-butyldimethylsilyl (TBDMS) derivatives of cyclophosphamide, another two are TBDMS derivatives of 4-hydroxy-eyelophosphamide, and one is from underivatized cyclophosphamide. The simultaneous detection of chlorine-containing compounds confirmed our results for those peaks related to cyclophosphamide and its metabolite.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 16:04:39