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Titolo:
SERUM LEPTIN LEVELS FOLLOWING HYPOTHALAMIC SURGERY
Autore:
BRABANT G; HORN R; MAYR B; VONZURMUHLEN A; HONEGGER J; BUCHFELDER M;
Indirizzi:
HANNOVER MED SCH,ABT KLIN ENDOKRINOL,KONSTANTY GUTSCHOWSTR 8 D-30623 HANNOVER GERMANY UNIV ERLANGEN NURNBERG,NEUROCHIRURG KLIN D-8520 ERLANGEN GERMANY
Titolo Testata:
Hormone and Metabolic Research
fascicolo: 12, volume: 28, anno: 1996,
pagine: 728 - 731
SICI:
0018-5043(1996)28:12<728:SLLFHS>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
OBESE OB GENE; MESSENGER-RNA; EXPRESSION; PROTEIN; MOUSE; WEIGHT;
Keywords:
OB GENE; CRANIOPHARYNGIOMA; PITUITARY ADENOMA; RHGH; OBESITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
G. Brabant et al., "SERUM LEPTIN LEVELS FOLLOWING HYPOTHALAMIC SURGERY", Hormone and Metabolic Research, 28(12), 1996, pp. 728-731

Abstract

To study a potential alteration of hypothalamic centers involved in the negative feedback action of leptin on body weight, serum leptin levels were measured in relation to BMI in 18 patients following surgery for a hypothalamic craniopharyngioma (Ctx), and were compared to levels found in 21 patients operated for a pituitary adenoma (Ptx) or in healthy control subjects. All subjects with Ptx received rhGH replacement therapy (0.5 to 2 IU/m(2)/d), and serum leptin levels were followed in 3 months intervals over 24 months. Serum leptin levels in patients with Ptx were comparable to controls, whereas 7 of the 18 patients with Ctx had higher than expected concentrations for their BMI. GH treatment in Ptx subjects did not alter serum leptin levels. In 5 Ctx patients where preoperative samples were available, weight gain in parallel to an increase in serum leptin levels was observed but only minimal changes in 4 others. Our data support the role of leptin as an importantmarker of body weight. The rapid increase in serum leptin levels observed in some Ctx subjects suggests that early postoperative measurement of serum leptin levels may help to identify patients at risk of weight gain following hypothalamic destruction.

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Documento generato il 01/12/20 alle ore 07:52:10