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Titolo:
FATAL EPSTEIN-BARR VIRUS-ASSOCIATED LYMPHOPROLIFERATIVE DISORDER IN CHILDHOOD
Autore:
YATABE Y; MORI N; OKA K; IIJIMA T; SAGA S; TAKADA K; ASAI J;
Indirizzi:
NAGOYA UNIV,SCH MED,DEPT PATHOL 1,SHOWA KU,65 TSURUMA CHO NAGOYA AICHI 466 JAPAN NATL INST RADIOL SCI,HOSP CLIN LAB SECT CHIBA JAPAN UNIV TSUKUBA,SCH MED,DEPT PATHOL IBARAKI OSAKA JAPAN NAGOYA UNIV,SCH MED,DEPT PATHOL 2 NAGOYA AICHI JAPAN YAMAGUCHI UNIV,SCH MED,DEPT VIROL & PARASITOL YAMAGUCHI JAPAN
Titolo Testata:
Archives of pathology and laboratory medicine
fascicolo: 5, volume: 119, anno: 1995,
pagine: 409 - 417
SICI:
0003-9985(1995)119:5<409:FEVLDI>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEMOPHAGOCYTIC SYNDROME; INFECTIOUS-MONONUCLEOSIS; IMMUNOBLASTIC LYMPHOMA; TRANSPLANT RECIPIENTS; DISEASE; IMMUNOPEROXIDASE; HYBRIDIZATION; FAMILIES; INSITU;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
Y. Yatabe et al., "FATAL EPSTEIN-BARR VIRUS-ASSOCIATED LYMPHOPROLIFERATIVE DISORDER IN CHILDHOOD", Archives of pathology and laboratory medicine, 119(5), 1995, pp. 409-417

Abstract

Objective.-We report five childhood cases of fatal Epstein-Barr virus-associated lymphoproliferative disorder to determine their immunopathologic and immunogenotypic features. Design.-Clinicopathologic features are described, using clinical, histologic, immunophenotypic, and genotypic examinations. Setting.-Autopsy cases were performed at Nagoya and Tsukuba university hospitals, Japan. Results.-Infiltrating lymphocytes, which were positive for the EBV genome by in situ hybridization, were polymorphic and showed polyclonal immunoglobulin staining in all five cases. Two cases, however, showed genetic clonality of EBV termini. In one case; the clonality was observed only in the spleen, and in the other case, clonal rearrangement of the JH gene was also found. The former case showed none of the morphologic features of neoplasia andpresented a morphology similar to virus-associated hemophagocytic syndrome. In the latter case, infiltrating lymphoid cells were much less polymorphous, and nodular masses of the lymphoid cells in colon and lung specimens were observed. Conclusion.-We suggest that some polyclonal EBV-associated lymphoproliferative disorders develop into polymorphic, but genotypically monoclonal, lymphoproliferative disorders.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 06:21:58