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Titolo:
DTG-INDUCED CIRCLING BEHAVIOR IN RATS MAY INVOLVE THE INTERACTION BETWEEN SIGMA-SITES AND NIGRO-STRIATAL DOPAMINERGIC PATHWAYS
Autore:
BASTIANETTO S; ROUQUIER L; PERRAULT G; SANGER DJ;
Indirizzi:
SYNTHELABO RECH,31 AVE PV COUTURIER F-92220 BAGNEUX FRANCE SYNTHELABO RECH F-92220 BAGNEUX FRANCE
Titolo Testata:
Neuropharmacology
fascicolo: 3, volume: 34, anno: 1995,
pagine: 281 - 287
SICI:
0028-3908(1995)34:3<281:DCBIRM>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
GUINEA-PIG BRAIN; SUBSTITUTED BENZAMIDE DRUGS; BINDING-SITES; ANTIPSYCHOTIC-DRUGS; RECEPTOR AGONIST; NEURONS; ANTAGONISTS; LIGANDS; SYSTEM; OPIATES;
Keywords:
SIGMA SITES; CIRCLING BEHAVIOR; DI-O-TOLYLGUANIDINE (DTG); DOPAMINERGIC SYSTEM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
S. Bastianetto et al., "DTG-INDUCED CIRCLING BEHAVIOR IN RATS MAY INVOLVE THE INTERACTION BETWEEN SIGMA-SITES AND NIGRO-STRIATAL DOPAMINERGIC PATHWAYS", Neuropharmacology, 34(3), 1995, pp. 281-287

Abstract

The distribution of a sites in brain areas enriched in dopamine, and the finding that circling behaviour can be elicited by specific a ligands such as DTG (di-o-tolylguanidine) suggest a modulatory role of these sites in the dopaminergic system. The present study was carried outto investigate further this hypothesis. Circling behaviour induced inrats by unilateral intranigral injection of DTG (10 nmol/rat) was decreased by haloperidol (0.1 mg/kg, i.p.), clebopride (0.25 mg/kg, i.p.)and SCH 23390 (0.03 mg/kg, s.c.) indicating that an interaction between a sites and the midbrain dopaminergic system may be involved in this rotational behaviour. Microdialysis experiments in freely moving rats showed that unilateral intranigral injection of DTG (5, 10, 20 nmol/rat) produced increases in extracellular levels of dopamine metabolites (DOPAC, HVA) in the ipsilateral striatum which correlated with the number of rotations. In addition intranigral injection of DTG (10 nmol/rat) produced increases in tissular dopamine metabolite levels in the ipsilateral striatum without affecting dopamine metabolite levels in limbic structures. These results indicate that a sites may be involved in the modulation of the dopaminergic motor system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 18:25:49