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Titolo:
PATHWAYS FROM HEMATOPOIETIC STEM-CELLS TO THYMOCYTES
Autore:
RODEWALD HR;
Indirizzi:
BASEL INST IMMUNOL,GRENZACHERSTR 476 CH-4005 BASEL SWITZERLAND
Titolo Testata:
Current opinion in immunology
fascicolo: 2, volume: 7, anno: 1995,
pagine: 176 - 187
SICI:
0952-7915(1995)7:2<176:PFHSTT>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR-BETA-CHAIN; COLONY-FORMING CELLS; UMBILICAL-CORD BLOOD; FC-GAMMA-RII/III; T-CELLS; C-KIT; PROGENITOR CELLS; PRECURSOR CELLS; LYMPHOCYTES-T; INTERLEUKIN-2 DEFICIENT;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
83
Recensione:
Indirizzi per estratti:
Citazione:
H.R. Rodewald, "PATHWAYS FROM HEMATOPOIETIC STEM-CELLS TO THYMOCYTES", Current opinion in immunology, 7(2), 1995, pp. 176-187

Abstract

A long-standing debate has been whether commitment to the T cell lineage occurs exclusively following thymus colonization, or whether prethymic T lineage restricted progenitors exist. Recently, the analysis ofmurine fetal blood for the presence of hematopoietic progenitor cellshas led to the identification of a T lineage committed precursor population (designated prothymocytes). Fetal blood prothymocytes lack multipotent progenitor potential as shown by the fact that they fail to reconstitute B lymphocyte, myeloid and erythroid lineages. In addition to prothymocytes, fetal blood also contains a phenotypically distinct, pluripotent progenitor population which can reconstitute both T and B lymphocytes as well as myeloid and erythroid lineages. The identification of a circulating, T lineage restricted precursor population, whichis also found in the blood of fetal athymic mice, provides strong evidence that T lineage commitment can precede thymus colonization. The thymus is not, however, exclusively colonized by prothymocytes. Under appropriate developmental conditions, multipotent precursor activity for non-T lineages such as B lymphocytes and thymic dendritic cells can be revealed within the intrathymic precursor pool. Moreover, evidence has been accumulated for a common progenitor for T cells and natural killer cells which may be distinct from multipotent intrathymic progenitors.

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Documento generato il 27/11/20 alle ore 03:50:12