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Titolo:
USE OF SYSTEM PEAKS IN LIQUID-CHROMATOGRAPHY FOR CONTINUOUS ONLINE MONITORING OF CHEMICAL-REACTIONS
Autore:
MIZROTSKY N; GRUSHKA E;
Indirizzi:
HEBREW UNIV JERUSALEM,DEPT INORGAN & ANALYT CHEM IL-91904 JERUSALEM ISRAEL HEBREW UNIV JERUSALEM,DEPT INORGAN & ANALYT CHEM IL-91904 JERUSALEM ISRAEL
Titolo Testata:
Analytical chemistry
fascicolo: 10, volume: 67, anno: 1995,
pagine: 1737 - 1741
SICI:
0003-2700(1995)67:10<1737:UOSPIL>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
PAIR ADSORPTION CHROMATOGRAPHY; REVERSED-PHASE CHROMATOGRAPHY; STATIONARY PHASES; COMPRESSION; COMPONENTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
N. Mizrotsky e E. Grushka, "USE OF SYSTEM PEAKS IN LIQUID-CHROMATOGRAPHY FOR CONTINUOUS ONLINE MONITORING OF CHEMICAL-REACTIONS", Analytical chemistry, 67(10), 1995, pp. 1737-1741

Abstract

System peaks, which occur in chromatography with multicomponent mobile phases, can be used for the continuous on-line monitoring of chemical reactions. The mobile phase reservoir is the chemical reactor, and the mobile phase, which contains the reaction mixture, is recycled continuously through the column, At predetermined times, a neat solvent normally the solvent of the reaction, is injected, The system peaks thatresult reflect the status of the reaction, We describe here the use of system peaks to follow the progress of two reactions: titration of aniline and hydrolysis of aspirin, In the case of aniline titration, weobtained a titration curve by plotting the capacity ratio of the aniline system peak versus the acid volume added during the titration, Theexperimental endpoint agreed very well with the theoretical equivalence point. A plot of the capacity factor as a function of mobile phase pH behaves similarly to such plots in conventional chromatography. In the hydrolysis of aspirin, we followed the progress of the reaction bymonitoring the formation of salicylic acid via its system peak, The data allowed us to calculate the apparent hydrolysis rate constant. Thevalue obtained is in excellent agreement with literature values.

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Documento generato il 19/09/20 alle ore 07:24:35