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Titolo:
AIDS-RELATED BURKITTS-LYMPHOMA - MORPHOLOGIC AND IMMUNOPHENOTYPIC STUDY OF BIOPSY SPECIMENS
Autore:
CARBONE A; GLOGHINI A; GAIDANO G; CILIA AM; BASSI P; POLITO P; VACCHER E; SAGLIO G; TIRELLI U;
Indirizzi:
INRCCS,CTR REG RIFERIMENTO ONOCOL,DIV PATHOL,VIA PEDEMONTANA OCCIDENTALE I-33081 AVIANO ITALY UNIV TURIN,DIPARTIMENTO SCI BIOMED & ONCOL UMANA TURIN ITALY IST NAZL RICOVERO & CURA & CARATTERE SCI,CTR REG RIFERIMENTO ONCOL,MED ONCOL & AIDS PROGRAM AVIANO ITALY
Titolo Testata:
American journal of clinical pathology
fascicolo: 5, volume: 103, anno: 1995,
pagine: 561 - 567
SICI:
0002-9173(1995)103:5<561:AB-MAI>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACQUIRED-IMMUNODEFICIENCY-SYNDROME; EPSTEIN-BARR-VIRUS; NON-HODGKINS-LYMPHOMAS; HISTOPATHOLOGY; HYBRIDIZATION; MALIGNANCIES; ASSOCIATION; ANTIBODIES; INFECTION;
Keywords:
AIDS-RELATED LYMPHOMAS; BURKITTS LYMPHOMA; SMALL NONCLEAVED CELL LYMPHOMA; IMMUNOBLASTIC LYMPHOMA; LYMPHOMA WITH INTERMEDIATE FEATURES; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
A. Carbone et al., "AIDS-RELATED BURKITTS-LYMPHOMA - MORPHOLOGIC AND IMMUNOPHENOTYPIC STUDY OF BIOPSY SPECIMENS", American journal of clinical pathology, 103(5), 1995, pp. 561-567

Abstract

In patients infected with HIV, high-grade B-cell non-Hodgkin's lymphomas (NHL), including the small noncleaved cell (SNCC) category, exhibit pleomorphic features, which makes precise definition difficult, Sixty-nine pathologic specimens with HIV-related systemic lymphomas, including 42 SNCC, 20 immunoblastic lymphomas (IBL), and 7 cases with features ''intermediate'' between SNCC and IBL were morphologically and immunophenotypically investigated. The host immune status was also analyzed in 57 of 69 patients. In 29 representative SNCC lymphomas, in 9 IBLcases, and an additional 3 intermediate lymphomas, both p53 protein overexpression and the association of Epstein-Barr virus (EBV) genetic information were assessed. Small noncleaved cell lymphomas included tumors exhibiting features of the 2 established subtypes (27 Burkitt's and 15 non-Burkitt's). In the seven intermediate cases, cells showed features intermediate between SNCC with plasmablastic differentiation and immunoblasts plasmacytoid. Immunoblast-like cells were also present,p53 protein overexpression and EBV association were found in a proportion of SNCC (14 of 29; 7 of 29) and intermediate (3 of 3; 2 of 3) lymphomas. Conversely, IBL cases were consistently p53 negative, but showed a high EBV association (7 of 9), All the evaluated patients with intermediate lymphomas had a considerably lower mean (76.6 per mm(3) +/-77.4 SD) and median (54 per mm(3)) number of CD4+ lymphocyte count than SNCC patients (mean 227.9 per mm(3) +/- 186.9 SD, median 193 per mm(3)), thus mirroring IBL patients (mean 95.3 per mm(3) +/- 82.8 SD, median 81 per mm(3)). All data provide evidence that lymphomas showing intermediate features constitute a distinct subgroup from either SNCC or IBL.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 03:47:58