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Titolo:
CARDIAC-CARDIOVASCULAR REFLEXES INDUCED BY HYDROGEN-PEROXIDE IN CATS
Autore:
HUANG HS; STAHL GL; LONGHURST JC;
Indirizzi:
UNIV CALIF DAVIS,DEPT INTERNAL MED,DIV CARDIOVASC MED,TB 172 DAVIS CA95616 UNIV CALIF DAVIS,DEPT INTERNAL MED,DIV CARDIOVASC MED DAVIS CA 95616 UNIV CALIF DAVIS,DEPT HUMAN PHYSIOL,DIV CARDIOVASC MED DAVIS CA 95616
Titolo Testata:
American journal of physiology. Heart and circulatory physiology
fascicolo: 5, volume: 37, anno: 1995,
pagine: 2114 - 2124
SICI:
0363-6135(1995)37:5<2114:CRIBHI>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
VAGAL AFFERENT INHIBITION; SYMPATHETIC-NERVE FIBERS; CORONARY-ARTERY OCCLUSION; MYOCARDIAL-ISCHEMIA; HYDROXYL RADICALS; SPINOTHALAMIC NEURONS; EPICARDIAL BRADYKININ; SUPEROXIDE-DISMUTASE; REPERFUSION; RESPONSES;
Keywords:
BILATERAL CERVICAL VAGOTOMY; T-1-T-4 GANGLIONECTOMY; DIMETHYLTHIOUREA; DEFEROXAMINE; ASPIRIN; PRESSER OR DEPRESSOR REFLEX RESPONSES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
H.S. Huang et al., "CARDIAC-CARDIOVASCULAR REFLEXES INDUCED BY HYDROGEN-PEROXIDE IN CATS", American journal of physiology. Heart and circulatory physiology, 37(5), 1995, pp. 2114-2124

Abstract

We have shown previously that reactive oxygen species stimulate abdominal sympathetic afferents to cause reflex cardiovascular activation. Because myocardial ischemia and reperfusion also generate reactive oxygen species, we investigated the possibility that cardiovascular reflexes could be induced by topical application of H2O2 to the anterior orposterior ventricular surface in cats anesthetized with alpha-chloralose. Mean arterial pressure (MAP), heart rate (HR), left ventricular (LV) pressure, aortic flow (AF), and first derivative of LV pressure at40 mmHg developed pressure (LV dP/dt(40)) were monitored. H2O2 (44 and 130 mu mol) significantly increased MAP but not HR or LV dP/dt(40) in intact cats (n = 8). Application of H2O2 (44 mu mol) significantly increased MAP (129 +/- 9 to 152 +/- 10 mmHg), HR (240 +/- 11 to 245 +/-10 beats/min), AF (191 +/- 13 to 212 +/- 17 ml/min), total peripheralresistance (0.68 +/- 0.13 to 0.73 +/- 0.04 peripheral resistance units), and LV dP/dt(40) (2,666 +/- 145 to 3,012 +/- 205 mmHg/s) after bilateral cervical vagotomy (n = 6). These H2O2-induced excitatory responses were abolished after bilateral T-1-T-4 ganglionectomy. In six additional cats, H2O2 (44 mu mol) significantly decreased MAP (114 +/- 5 to 102 +/- 5 mmHg), HR (207 +/- 7 to 190 +/- 7 beats/min), and LV dP/dt(40) (2,776 +/- 168 to 2,600 +/- 153 mmHg/s) after sympathectomy. These depressor responses were eliminated after vagotomy. The magnitude ofthe cardiovascular reflexes was increased or decreased in a dose-dependent fashion in vagotomized or sympathectomized cats, respectively, over a range of 440 nmol to 44 mu mol H2O2. Application of H2O2 to the anterior or posterior ventricular surface resulted in similar presser or depressor reflexes. Dimethylthiourea and deferoxamine abolished presser or depressor responses evoked by H2O2 in both vagotomized (n = 8)and sympathectomized (n = 8) cats. We conclude that reactive oxygen species, particularly the hydroxyl radical, can participate in activating cardiac afferents responsible for reflex cardiovascular responses during myocardial ischemia and reperfusion. An inhibitory reflex is transmitted through vagal afferents, whereas an excitatory reflex is conducted by sympathetic cardiac afferents.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 19:06:46