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Titolo:
VISCOELASTIC BEHAVIOR OF IN-SITU AORTIC-WALL DURING HEMORRHAGIC HYPOTENSION
Autore:
XAVIERNETO J; KRIEGER EM;
Indirizzi:
UNIV SAO PAULO,FAC MED,INST CORACAO,UNIDADE HIPERTENSAO,RUA DR ENEAS CARVALHO AGUIAR 44 BR-05403000 SAO PAULO BRAZIL UNIV SAO PAULO,FAC MED,INST CORACAO,UNIDADE HIPERTENSAO BR-05403000 SAO PAULO BRAZIL
Titolo Testata:
American journal of physiology. Heart and circulatory physiology
fascicolo: 5, volume: 37, anno: 1995,
pagine: 1773 - 1780
SICI:
0363-6135(1995)37:5<1773:VBOIAD>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPONTANEOUSLY HYPERTENSIVE RATS; CAROTID-SINUS; ARTERIAL BARORECEPTORS; ENDOTHELIAL-CELLS; DOGS; MECHANICS; FLOW;
Keywords:
SMOOTH MUSCLE; VISCOELASTICITY; BARORECEPTOR; RESETTING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
J. Xavierneto e E.M. Krieger, "VISCOELASTIC BEHAVIOR OF IN-SITU AORTIC-WALL DURING HEMORRHAGIC HYPOTENSION", American journal of physiology. Heart and circulatory physiology, 37(5), 1995, pp. 1773-1780

Abstract

Viscoelastic and electrophysiological mechanisms have been implicatedin resetting of baroreceptors in hypertension, but resetting in response to hypotension has been less exhaustively studied. To assess the importance of viscoelastic mechanisms in hypotension, we examined the behavior of the ''in situ'' aorta during hemorrhage. Fifteen minutes ofhemorrhage in anesthetized Wistar rats produced stable hypotension (30 mmHg) and a progressive contraction of the mean aortic caliber (-93.8 +/- 18.0 mu m, P < 0.05) compared with control measurements. Contraction was not altered by sinoaortic denervation, vagotomy, nephrectomy,adrenalectomy, hexamethonium (30 mg/kg), losartan (10 mg/kg), V-1 antagonist (10 mu g/kg), arterial pH and blood gas control, or indomethacin (3.0 mg/kg). Aortic contraction was greater in rats treated with N-omega-nitro-L-arginine (-164.0 +/- 43.0 mu m, P < 0.05) than in those treated with sodium nitroprusside (-54.1 +/- 7.5 mu m, P < 0.05). The results indicate that aortic contraction is compatible with viscoelastic contraction and suggest that shortening of viscoelastic elements inseries with baroreceptor endings increases stress at the baroreceptormembrane and contributes to the development of baroreceptor resettingto hypotension.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 22:14:39