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Titolo:
GLIONEUROCYTOMA - TUMOR WITH GLIAL AND NEURONAL DIFFERENTIATION
Autore:
MIN KW; CASHMAN RE; BRUMBACK RA;
Indirizzi:
UNIV OKLAHOMA,HLTH SCI CTR,DEPT PATHOL,POB 26307 OKLAHOMA CITY OK 73104
Titolo Testata:
Journal of child neurology
fascicolo: 3, volume: 10, anno: 1995,
pagine: 219 - 226
SICI:
0883-0738(1995)10:3<219:G-TWGA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; DYSEMBRYOPLASTIC NEUROEPITHELIAL TUMOR; CENTRAL NEUROCYTOMA; INTRAVENTRICULAR NEUROCYTOMA; PILOCYTIC ASTROCYTOMAS; STEM-CELLS; BLASTOMA; ADULTS; NEUROBLASTOMA; NEOPLASMS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
K.W. Min et al., "GLIONEUROCYTOMA - TUMOR WITH GLIAL AND NEURONAL DIFFERENTIATION", Journal of child neurology, 10(3), 1995, pp. 219-226

Abstract

We report two cases of low-grade glioma in which multiple cellular components, including cells with dense-core granules consistent with ''neurocytes,'' were identified on electron microscopic studies. The first patient was an apparently normal boy until the onset of seizures at age 10 months. Initially, the seizures improved with phenobarbital treatment, but good seizure control was never achieved. Computed tomographic scan at age 23 months showed a calcified, nonenhancing left parietal mass. This tumor was composed of sheets of cells with clear cytoplasm and round to oval nuclei. Mucinous intercellular material stained positively with periodic acid-Schiff, mucicarmine, and alcian blue stains. Foci of calcification were evident. The second patient was a 13-year-old boy with a left parasagittal parieto-occipital mass who presented with a 4-month history of seizures and declining school performance. The tumor was composed of sheets of astrocytes with dark, hyperchromatic, pleomorphic nuclei in a fibrillary and microcystic background. The tumor contained the pleomorphism seen in the adult variant of pilocytic astrocytoma, as well as the microcystic component seen in the juvenile variety. Ultrastructurally in both cases, there were occasional tumor cells having round to oval nuclei with moderate amounts of cytoplasm containing 150- to 250-nm-diameter dense-core granules. These cells were admired with the majority of tumor cells, which in case 1 had the ultrastructural features of astrocytes and oligodendrocytes and incase 2 had features of protoplasmic or pilocytic astrocytes. Our cases bear superficial resemblance to dysembryoplastic neuroepithelial tumors; however, dysplastic ganglion cells are an essential component forthat diagnosis, and there were no dysplastic ganglion cells in eitherof our cases. Cells containing dense-core granules (neurocytes) were found in both our cases by electron microscopy and appear to be a partof a neoplastic process. The significance of neurocytes in low-grade gliomas is not known. Cerebral tumors consisting of neuroblasts/neurocytes in toto or in part have been increasingly recognized in recent years, and our cases add to the spectrum of such neoplasms.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 15:21:36