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Titolo:
GENETIC-ANALYSIS PRIOR TO SELECTIVE FETAL REDUCTION IN MULTIPLE PREGNANCY - TECHNICAL ASPECTS AND CLINICAL OUTCOME
Autore:
BRAMBATI B; TULUI L; BALDI M; GUERCILENA S;
Indirizzi:
VIA COMMENDA 12 I-20122 MILAN ITALY UNIV MILAN,INST OBSTET & GYNECOL 1 MILAN ITALY REPROD MED CTR MILAN ITALY CTR HUMAN GENET ROME ITALY IST CLIN PERFEZIONMENTO,INST OCCUPAT HLTH,EPIDEMIOL UNIT MILAN ITALY
Titolo Testata:
Human reproduction
fascicolo: 4, volume: 10, anno: 1995,
pagine: 818 - 825
SICI:
0268-1161(1995)10:4<818:GPTSFR>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
MULTIFETAL PREGNANCIES; QUADRUPLET PREGNANCIES; EMBRYO REDUCTION; 1ST TRIMESTER; GESTATION; MANAGEMENT; ABNORMALITIES; AMNIOCENTESIS; TERMINATION; EXPERIENCE;
Keywords:
GENETIC DIAGNOSIS; MULTIPLE PREGNANCY; REDUCTION SINGLETONS; TWINS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
54
Recensione:
Indirizzi per estratti:
Citazione:
B. Brambati et al., "GENETIC-ANALYSIS PRIOR TO SELECTIVE FETAL REDUCTION IN MULTIPLE PREGNANCY - TECHNICAL ASPECTS AND CLINICAL OUTCOME", Human reproduction, 10(4), 1995, pp. 818-825

Abstract

Multiple pregnancies resulting from ovarian stimulation are at a higher risk of carrying at least one fetus affected by Mendelian or chromosomal anomalies, the incidence of which is directly related to the order of multiples, Genetic analysis before fetal reduction was offered to both high- and low-risk pregnant women carrying two or more fetuses after ovulation induction, Chorionic villus sampling (CVS) and fetal reduction were achieved by transabdominal needling, The use of short-term culture, the polymerase chain reaction and fresh tissue enzymatic analyses have made it possible for genetic diagnosis to be available ina few days. A total of 100 patients had multifetal pregnancy reduction performed by a single operator; all of them completed pregnancy and none was lost at follow-up, The total fetal loss before 24 weeks was 7% and no statistically significant relationship was found with the final number of fetuses and CVS, Perinatal losses (3.9%) were only present in the series with a final number of two fetuses, Pregnancy durationand birthweight were significantly higher in singletons than in twins, but were not related to CVS, The rate of chromosomal disorders was higher (7.2%) in the study series than in singleton pregnancies not undergoing fetal reduction, Diagnostic error due to incorrect sampling was reported in 1.5% of cases, These data support fetal reduction as a valuable strategy to improve the outcome of multiple pregnancy, The outcome of pregnancies reduced to singletons was significantly better than of those reduced to twins, and was not related to CVS, Therefore, prenatal genetic diagnosis should become an integral part of counsellingon multiple pregnancy, and is strongly recommended when reduction to singleton pregnancy is requested.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 22:40:19