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Titolo:
PREJUNCTIONAL ACTIONS OF MUSCLE-RELAXANTS - SYNAPTIC VESICLES AND TRANSMITTER MOBILIZATION AS SITES OF ACTION
Autore:
PRIOR C; TIAN L; DEMPSTER J; MARSHALL IG;
Indirizzi:
UNIV STRATHCLYDE,ROYAL COLL,DEPT PHYSIOL & PHARMACOL,204 GEORGE ST GLASGOW G1 1XW LANARK SCOTLAND
Titolo Testata:
General pharmacology
fascicolo: 4, volume: 26, anno: 1995,
pagine: 659 - 666
SICI:
0306-3623(1995)26:4<659:PAOM-S>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOTOR-NERVE TERMINALS; RAT CENTRAL NEURONS; NEUROMUSCULAR-JUNCTION; ACETYLCHOLINE-RECEPTOR; REPETITIVE STIMULATION; NICOTINIC ANTAGONISTS; CALCIUM PERMEABILITY; BLOCKING ACTIVITIES; PHRENIC-NERVE; TETANIC FADE;
Keywords:
ACETYLCHOLINE RELEASE; MOTOR NERVE TERMINALS; PREJUNCTIONAL RECEPTORS; TUBOCURAINE; VECURONIUM; VESAMICOL;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
C. Prior et al., "PREJUNCTIONAL ACTIONS OF MUSCLE-RELAXANTS - SYNAPTIC VESICLES AND TRANSMITTER MOBILIZATION AS SITES OF ACTION", General pharmacology, 26(4), 1995, pp. 659-666

Abstract

1. Nicotinic antagonists such as tubocurarine affect acetylcholine release from motor nerve terminals at the neuromuscular junction. 2. Electrophysiological studies comparing the prejunctional actions of tubocurarine to those of vesamicol and vecuronium have been used to providean insight into the mechanisms involved in the prejunctional effects of tubocurarine-like compounds. 3. The observed prejunctional actions of tubocurarine can be accounted for by a model in which the compound has two separately identifiable effects on the nerve terminal. At low frequencies of nerve stimulation tubocurarine augments acetylcholine release while at high frequencies of nerve stimulation tubocurarine depresses acetylcholine release. 4. Both of the effects of tubocurarine on acetylcholine release are a consequence of a change in the number ofquanta within the nerve terminal immediately available for release upon nerve stimulation. 5. On the basis of our experimental observations, we suggest that the two prejunctional effects of tubocurarine are mediated through two pharmacologically distinct prejunctional nAChRs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 08:49:09