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Titolo:
AGE, GENDER, AND VASOPRESSIN AFFECT SURVIVAL AND BRAIN ADAPTATION IN RATS WITH METABOLIC ENCEPHALOPATHY
Autore:
ARIEFF AI; KOZNIEWSKA E; ROBERTS TPL; VEXLER ZS; AYUS JC; KUCHARCZYK J;
Indirizzi:
VET AFFAIRS MED CTR,DEPT MED,GERIATR SECT,4150 CLEMENT ST SAN FRANCISCO CA 94121 BAYLOR COLL MED,DEPT MED HOUSTON TX 77024 UNIV CALIF SAN FRANCISCO,NEURORADIOL SECT SAN FRANCISCO CA 94121
Titolo Testata:
American journal of physiology. Regulatory, integrative and comparative physiology
fascicolo: 5, volume: 37, anno: 1995,
pagine: 1143 - 1152
SICI:
0363-6119(1995)37:5<1143:AGAVAS>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARGININE VASOPRESSIN; FEMALE RATS; BLOOD-FLOW; HYPONATREMIA; CHILDREN;
Keywords:
HYPONATREMIA; ESTROGEN; TESTOSTERONE; CEREBRAL PERFUSION; GONADAL STEROIDS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
A.I. Arieff et al., "AGE, GENDER, AND VASOPRESSIN AFFECT SURVIVAL AND BRAIN ADAPTATION IN RATS WITH METABOLIC ENCEPHALOPATHY", American journal of physiology. Regulatory, integrative and comparative physiology, 37(5), 1995, pp. 1143-1152

Abstract

Children and menstruant women are far more likely than men to developmetabolic brain damage from hyponatremia. We evaluated brain adaptation and mortality from hyponatremia in male and female rats of three different age groups. With acute hyponatremia, the mortality was 84% in prepubertal rats vs. 15% in adults and 0% in elderly rats. With chronic hyponatremia, mortality was 13% in adult males vs. 62% in females. Testosterone pretreatment significantly decreased mortality (from 62 to9% in adult females, and from 100% to zero in prepubertal rats), but estrogen significantly increased mortality (from 13 to 44% in adult males). With acute hyponatremia in adult rats, brain sodium was significantly decreased (-17%), but in prepubertal rats it was actually increased (+37%). Cerebral perfusion during chronic hyponatremia was significantly impaired in adult females vs. males or controls (P < 0.01). Neither vasopressin administration nor chronic hyponatremia induced with desmopressin resulted in any mortality or decrement of cerebral perfusion. Thus age, gender, and the cerebral effects of vasopressin are major determinants of mortality in experimental metabolic encephalopathy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 22:59:41