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Titolo:
THE INFLUENCE OF BAY K-8644 TREATMENT ON (+ -)-EPIBATIDINE-INDUCED ANALGESIA/
Autore:
BANNON AW; GUNTHER KL; DECKER MW; ARNERIC SP;
Indirizzi:
ABBOTT LABS,DIV PHARMACEUT PROD,DEPT 47W,NEUROSCI DISCOVERY,BLDG AP-9ALL,100 ABBOTT PK RD ABBOTT PK IL 60064
Titolo Testata:
Brain research
fascicolo: 1-2, volume: 678, anno: 1995,
pagine: 244 - 250
SICI:
0006-8993(1995)678:1-2<244:TIOBKT>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
NICOTINE-INDUCED ANTINOCICEPTION; RAT CENTRAL NEURONS; CALCIUM; RECEPTOR;
Keywords:
EPIBATIDINE; NICOTINIC ACETYLCHOLINE RECEPTOR; BAY K 8644; ANALGESIA; CALCIUM CHANNEL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
A.W. Bannon et al., "THE INFLUENCE OF BAY K-8644 TREATMENT ON (+ -)-EPIBATIDINE-INDUCED ANALGESIA/", Brain research, 678(1-2), 1995, pp. 244-250

Abstract

The purpose of this investigation was to determine if analogous to (-)-nicotine's analgesic effect, the analgesic effect of the recently characterized potent nicotinic acetylcholine receptor (nAChR) agonist (+/-)-epibatidine was altered in response to treatment with the calcium channel agonist (+/-)-Bay K 8644. In addition, the effects of the enantiomers, (+)-Bay K 8644, reported to be a calcium channel antagonist, and (-)-Bay K 8644, reported to be a calcium channel agonist were examined. (+/-)-Bay K 8644 (2.8 mu mol/kg; i.p.) produced a large analgesic response in mice in the hot-plate paradigm that rapidly dissipated by 30 min after treatment. This analgesic effect of (+/-)-Bay K 8644 was not prevented by pre-treatment with the nicotinic antagonist mecamylamine (5 mu mol/kg; i.p.). Treatment with non-analgesic doses of the calcium channel agonists (+/-)- and (-)-Bay K 8644 (1.4 mu mol/kg; i.p.) significantly potentiated the analgesic effect of (+/-)-epibatidine (0.05 mu mol/kg; i.p.). Potentiation of (+/-)-epibatidine's analgesic effect occurred when the agonists were administered prior to (+/-)-epibatidine or after (+/-)-epibatidine as long as analgesia testing was conducted 15 to 30 min after Bay K 8644 treatment. Pre-treatment with the calcium channel antagonist (+)-Bay K 8644 was found to attenuate (+/-)-epibatidine-induced analgesia. When given after (+/-)-epibatidine,(+)-Bay K 8644 had no effect on (+/-)-epibatidine's analgesic effect. These data provide additional in vivo evidence that altering calcium dynamics can modulate neuronal nAChR function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 05:22:11