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Titolo:
HYPOXIA INDUCES CAPILLARY NETWORK FORMATION IN CULTURED BOVINE PULMONARY MICROVESSEL ENDOTHELIAL-CELLS
Autore:
PHILLIPS PG; BIRNBY LM; NARENDRAN A;
Indirizzi:
STRATTON DEPT VET AFFAIRS MED CTR,RES SERV 151D,113 HOLLAND AVE ALBANY NY 12208 ALBANY MED COLL,DEPT MED ALBANY NY 12208
Titolo Testata:
American journal of physiology. Lung cellular and molecular physiology
fascicolo: 5, volume: 12, anno: 1995,
pagine: 789 - 800
SICI:
1040-0605(1995)12:5<789:HICNFI>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANGIOGENESIS INVITRO; DNA-SYNTHESIS; LUNG REPAIR; GROWTH; IDENTIFICATION; MATRIX; PROCOLLAGENASE; PERMEABILITY; EXPRESSION; INCREASES;
Keywords:
IN VITRO ANGIOGENESIS; NEOVASCULARIZATION; OXYGEN; COLLAGEN GEL; MIGRATION; BASIC FIBROBLAST GROWTH FACTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
P.G. Phillips et al., "HYPOXIA INDUCES CAPILLARY NETWORK FORMATION IN CULTURED BOVINE PULMONARY MICROVESSEL ENDOTHELIAL-CELLS", American journal of physiology. Lung cellular and molecular physiology, 12(5), 1995, pp. 789-800

Abstract

The development of new vessels (angiogenesis) is essential to wound healing. The center of a wound space is hypoxic, a condition that has been shown to stimulate angiogenesis in animal models of coronary artery occlusion. Because the mechanisms involved in this complex process are difficult to study in situ, an in vitro model would provide a useful complement to in vivo studies. This laboratory has developed and characterized calf pulmonary microvessel endothelial cell (PMVEC) cultures and an in vitro model system of angiogenesis using collagen three-dimensional gels that permit migration of cells into vessel networks. This system was used to study the direct effect of normoxia (20% O-2) orhypoxia (5% O-2) on PMVEC ability to undergo angiogenesis in vitro. Major changes leading to formation of capillary-like networks occurred during the first 3 days of hypoxic exposure only and included restructuring of actin filament networks, focal changes in distribution of basic fibroblast growth factor, and orientation and migration of cell tracts into a collagen gel matrix to form vessel networks.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 13:51:00