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Titolo:
LEVOROTATORY FORM OF 5-HYDROXYTRYPTOPHAN IN FRIEDREICHS ATAXIA - RESULTS OF A DOUBLE-BLIND DRUG-PLACEBO COOPERATIVE STUDY
Autore:
TROUILLAS P; SERRATRICE G; LAPLANE D; RASCOL A; AUGUSTIN P; BARROCHE G; CLANET M; DEGOS CF; DESNUELLE C; DUMAS R; MICHEL D; VIALLET F; WARTER JM; ADELEINE P;
Indirizzi:
UNIV LYON 1,HOP NEUROL,FAC ALEXIS CARREL,ATAXIA RES CTR,59 BLVD PINNEL F-69003 LYON FRANCE UNIV LYON 1,HOP NEUROL,FAC ALEXIS CARREL,CEREBROVASC UNIT F-69003 LYON FRANCE HOP ENFANTS LA TIMONE,NEUROL CLIN MARSEILLE FRANCE HOP LA PITIE SALPETRIERE,MALAD SYST NERVEUX CLIN F-75651 PARIS FRANCE HOP PURPAN,NEUROL CLIN TOULOUSE FRANCE HOSPICES CIVIES STRASBOURG,SERV NEUROL STRASBOURG FRANCE HOP BELLEVUE ST ETIENNE FRANCE HOP ST JOSEPH F-75674 PARIS FRANCE HOP CHARLES NICOLLE ROUEN FRANCE HOP ST JULIEN NANCY FRANCE HOP GEN,NEUROL CLIN DIJON FRANCE HOP AIX EN PROVENCE,SERV NEUROL LYON FRANCE HOP LOUIS PASTEUR,SERV NEUROL LYON FRANCE UNIV LYON 1,FAC ALEXIS CARREL,BIOSTAT UNIT F-69365 LYON FRANCE
Titolo Testata:
Archives of neurology
fascicolo: 5, volume: 52, anno: 1995,
pagine: 456 - 460
SICI:
0003-9942(1995)52:5<456:LFO5IF>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBELLAR PURKINJE-CELLS; RAT CEREBELLUM; SEROTONIN; NEURONS; INHIBITION; RECEPTORS; RELEASE; 5-HT1; IMPROVEMENT; DISCHARGE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
P. Trouillas et al., "LEVOROTATORY FORM OF 5-HYDROXYTRYPTOPHAN IN FRIEDREICHS ATAXIA - RESULTS OF A DOUBLE-BLIND DRUG-PLACEBO COOPERATIVE STUDY", Archives of neurology, 52(5), 1995, pp. 456-460

Abstract

Objective: To study the effect of the levorotatory form of 5-hydroxytryptophan on the cerebellar symptoms of Friedreich's ataxia. Design: Cooperative double-blind study of the levorotatory form of 5-hydroxytryptophan vs placebo. Setting: Twelve centers in research hospitals. Patients: Twenty-six patients were included; 19 completed the study (mean/-SD age of patients, 25.9+/-8.1 years). Of these 19 patients, eight were treated with placebo and 11 were treated with the drug. Main Outcome Measures: A semiquantitative scale for kinetic and static (''postural'') cerebellar functions and quantitative measurements of time in standard tests that evaluated stance, speech, writing, and drawing. Results: In the active treatment group, a significant decrease of the kinetic score was observed (P=.03), indicating an improvement in coordination. Conclusions: These results demonstrated that the levorotatory form of 5-hydroxytryptophan is able to modify significantly the cerebellar symptoms in patients with Friedreich's ataxia. However, the effect is only partial and not clinically major.

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Documento generato il 29/10/20 alle ore 20:55:42