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Titolo:
SEQUENTIAL SUBCUTANEOUS THYMOPENTIN, INTERFERON ALPHA-2A AND INTERLEUKIN-2 IN METASTATIC RENAL-CELL CANCER
Autore:
DILAURO L; DELMEDICO P; CARPANO S; CANCRINI A; GIONFRA T; VICI P; ROSSELLI M; LOPEZ M;
Indirizzi:
IST REGINA ELENA STUDIO CURA TUMORI,DIV MED ONCOL 2,VIALE REGINA ELENA 291 I-00161 ROME ITALY REGINA ELENA INST CANC RES,DEPT UROL I-00161 ROME ITALY
Titolo Testata:
Tumori
fascicolo: 1, volume: 81, anno: 1995,
pagine: 42 - 44
SICI:
0300-8916(1995)81:1<42:SSTIAA>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHASE-II; CARCINOMA; COMBINATION; INFUSION; ALFA-2A; TRIAL;
Keywords:
INTERFERON ALPHA-2A; INTERLEUKIN-2; RENAL CELL CANCER; THYMOPENTIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
9
Recensione:
Indirizzi per estratti:
Citazione:
L. Dilauro et al., "SEQUENTIAL SUBCUTANEOUS THYMOPENTIN, INTERFERON ALPHA-2A AND INTERLEUKIN-2 IN METASTATIC RENAL-CELL CANCER", Tumori, 81(1), 1995, pp. 42-44

Abstract

To determine the activity of sequential administration of thymopentin(TP-5), interferon alpha-2a (IFN) and interleukin-2 (IL-2) in metastatic renal cell cancer (RCC), 17 patients with RCC were treated with TP-5 50 mg/d on days 1 to 14, IFN 3 MIU/d on days 14, 15, 21, 22 and IL-2 18 MIU/d on days 16 to 20, and 23 to 27. Treatment was given subcutaneously and cycles were repeated every 6 weeks. All patients were assessed for toxicity and response. No objective responses were observed. Two patients had a short-lived disease stabilization. Median survival was 9 months. Toxicity was generally moderate. The most important side-effects were related to IL-2 administration. In view of the lack of antitumor activity, the combination of TP-5 + IFN + IL-2 in the doses and schedule used in this trial cannot be recommended. The investigation of chemotherapeutic and immunological agents that can effectively synergize with IFN or IL-2 is essential.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 21:13:12